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Keynote webinar | Spotlight on sleep in brain health

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Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
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Breast Cancer Research
Published in: Breast Cancer Research 1/2010

01-05-2010 | Poster presentation

C-terminal binding proteins play a critical nuclear function in the mitotic fidelity of breast cancer cells

Authors: CN Birts, JP Blaydes

Published in: Breast Cancer Research | Special Issue 1/2010

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Excerpt

We are interested in finding novel therapeutic targets for breast cancer, particularly focusing on C-terminal binding proteins (CtBPs) as when they are inhibited, cells show an increased sensitivity to apoptotic stimuli. Using siRNA to inhibit CtBP expression, we have found that CtBPs are essential for the survival of breast cancer cells, and in particular those with a more aggressive p53-mutant phenotype. To direct our future studies into therapeutic strategies targeting CtBPs in breast cancer, we need to know more precisely how their loss results in death, and which of their functions are required for this prosurvival role. …
Metadata
Title
C-terminal binding proteins play a critical nuclear function in the mitotic fidelity of breast cancer cells
Authors
CN Birts
JP Blaydes
Publication date
01-05-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 1/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2515

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