Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 2/2005

01-06-2005 | Poster Presentation

Lack of evidence for nuclear IGFBP5 in mammary epithelial cells

Authors: C Berlato, A Jurgeit, S Geley, W Doppler

Published in: Breast Cancer Research | Special Issue 2/2005

Login to get access

Excerpt

IGFBP5 plays a role in mediating the effects of IGFs, which are important in mammary gland development [1] and carcinogenesis [2]. IGF-independent effects of IGFBP5 have also been described and it has been postulated that these are at least partially mediated via IGFBP5 localized in the nucleus [3, 4]. …
Literature
1.
Allan GJ, Beattie J, Flint DJ: The role of IGFBP-5 in mammary gland development and involution. Domest Anim Endocrinol. 2004, 27: 257-266. 10.1016/j.domaniend.2004.06.009.CrossRefPubMed
2.
Pollak MN, Schernhammer ES, Hankinson SE: Insulin-like growth factors and neoplasia. Nat Rev Cancer. 2004, 4: 505-518. 10.1038/nrc1387.CrossRefPubMed
3.
Schedlich LJ, Le Page SL, Firth SM, Briggs LJ, Jans DA, Baxter RC: Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit. J Biol Chem. 2000, 275: 23462-23470. 10.1074/jbc.M002208200.CrossRefPubMed
4.
Xu Q, Li S, Zhao Y, Maures TJ, Yin P, Duan C: Evidence that IGF binding protein-5 functions as a ligand-independent transcriptional regulator in vascular smooth muscle cells. Circ Res. 2004, 94: e46-e54. 10.1161/01.RES.0000124761.62846.DF.CrossRefPubMed
Metadata
Title
Lack of evidence for nuclear IGFBP5 in mammary epithelial cells
Authors
C Berlato
A Jurgeit
S Geley
W Doppler
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2005
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1142

Other articles of this Special Issue 2/2005

Breast Cancer Research 2/2005 Go to the issue

Poster Presentation

Identification of clinically relevant gene sets and pathways using functional models of breast tumor suppression

Poster Presentation

Breast tumors induce the recruitment of AC133+KDR+ endothelial precursor cells mobilized by plasma vascular endothelial growth factor

Poster Presentation

Comparative expressed sequence hybridisation revealed distinct chromosomal regions of differential gene expression in breast cancer subtypes

Oral Presentation

Tailored therapies based upon tumor subtype biology

Poster Presentation

Screening for germline rearrangements in BRCA1 and BRCA2in Norwegian families with breast or breast/ovarian cancer

Poster Presentation

HIN-1, an inhibitor of cell growth, invasion, and AKT1 activation
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits