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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2013

Open Access 01-02-2013 | Research article

Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests

Authors: Alessandra Vacca, Roberta Montisci, Pietro Garau, Paolo Siotto, Matteo Piga, Alberto Cauli, Massimo Ruscazio, Luigi Meloni, Sabino Iliceto, Alessandro Mathieu

Published in: Arthritis Research & Therapy | Issue 1/2013

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Abstract

Introduction

Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement. We assessed coronary microcirculation status by combining two functional tests in SSc patients and estimating its impact on disease outcome.

Methods

Forty-one SSc patients, asymptomatic for coronary artery disease, were tested for coronary flow velocity reserve (CFR) by transthoracic-echo-Doppler with adenosine infusion (A-TTE) and for left ventricular wall motion abnormalities (WMA) by dobutamine stress echocardiography (DSE). Myocardial multi-detector computed tomography (MDCT) enabled the presence of epicardial stenosis, which could interfere with the accuracy of the tests, to be excluded. Patient survival rate was assessed over a 6.7- ± 3.5-year follow-up.

Results

Nineteen out of 41 (46%) SSc patients had a reduced CFR (≤2.5) and in 16/41 (39%) a WMA was observed during DSE. Furthermore, 13/41 (32%) patients showed pathological CFR and WMA. An inverse correlation between wall motion score index (WMSI) during DSE and CFR value (r = -0.57, P <0.0001) was observed; in addition, CFR was significantly reduced (2.21 ± 0.38) in patients with WMA as compared to those without (2.94 ± 0.60) (P <0.0001). In 12 patients with abnormal DSE, MDCT was used to exclude macrovasculopathy. During a 6.7- ± 3.5-year follow-up seven patients with abnormal coronary functional tests died of disease-related causes, compared to only one patient with normal tests.

Conclusions

A-TTE and DSE tests are useful tools to detect non-invasively pre-clinical microcirculation abnormalities in SSc patients; moreover, abnormal CFR and WMA might be related to a worse disease outcome suggesting a prognostic value of these tests, similar to other myocardial diseases.
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Metadata
Title
Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests
Authors
Alessandra Vacca
Roberta Montisci
Pietro Garau
Paolo Siotto
Matteo Piga
Alberto Cauli
Massimo Ruscazio
Luigi Meloni
Sabino Iliceto
Alessandro Mathieu
Publication date
01-02-2013
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2013
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar4136

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