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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

An essential role of IκBζ in the transcriptional program in Th17 development

Authors: Kazuo Okamoto, Masatsugu Oh-hora, Hiroshi Takayanagi

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

IL-17-producing helper T (Th17) cells are a distinct T cell subset characterized by its pathological role in autoimmune diseases. Our group previously showed that Th17 cells function as osteoclastogenic helper T cells in bone destruction associated with inflammation, and that inhibition of Th17 development has the potential of a beneficial impact on bone diseases including rheumatoid arthritis (RA) [1]. It is therefore important to comprehend the molecular mechanism underlying Th17 development in order to develop ideal therapeutic strategies against RA. …
Literature
1.
Sato K, Suematsu A, Okamoto K, Yamaguchi A, Morishita Y, Kadono Y, Tanaka S, Kodama T, Akira S, Iwakura Y, Cua DJ, Takayanagi H: Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med. 2006, 203: 2673-2682. 10.1084/jem.20061775.PubMedCentralCrossRefPubMed
2.
Okamoto K, Iwai Y, Oh-Hora M, Yamamoto M, Morio T, Aoki K, Ohya K, Jetten AM, Akira S, Muta T, Takayanagi H: IκBζ regulates TH17 development by cooperating with ROR nuclear receptors. Nature. 2010, 464: 1381-1385. 10.1038/nature08922.CrossRefPubMed
Metadata
Title
An essential role of IκBζ in the transcriptional program in Th17 development
Authors
Kazuo Okamoto
Masatsugu Oh-hora
Hiroshi Takayanagi
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3691

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