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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Egr-1 mediates the suppressive effect of IL-1 on PPARg expression in human OA chondrocytes

Authors: Sarah S Nebbaki, Fatima Ezzahra El Mansouri, Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Hassan Fahmi

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Peroxisome proliferator-activated receptor gamma (PPARg) is a ligand activated transcription factor and member the nuclear hormone receptor superfamily. Several lines of evidence indicate that PPARg have protective effects in osteoarthritis (OA). Indeed, PPARg has been shown to down-regulate several inflammatory and catabolic responses in articular joint cells and to be protective in animal models of OA. We have previously shown that IL-1 down-regulated PPARg expression in OA chondrocytes. In the present study we will investigate the mechanisms underlying this effect of IL-1. …
Metadata
Title
Egr-1 mediates the suppressive effect of IL-1 on PPARg expression in human OA chondrocytes
Authors
Sarah S Nebbaki
Fatima Ezzahra El Mansouri
Mohamed Benderdour
Johanne Martel-Pelletier
Jean-Pierre Pelletier
Hassan Fahmi
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3613

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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Prof. Kevin Dolgin
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Developed by: Springer Medicine
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