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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

TGF-β signaling induces SnoN to suppress BMP-induced hypertrophic maturation of chondrocytes

Authors: Shingo Maeda, Ichiro Kawamura, Yasuhiro Ishidou, Katsuyuki Imamura, Masahiro Yokouchi, Setsuro Komiya

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Loss of TGF-β signaling in mice leads to promoted hypertrophic conversion of articular chondrocytes, which process is suggested to be linked to progression of osteoarthritis (OA). However, the molecular mechanisms by which TGF-β signaling inhibits chondrocyte maturation remain unclear. We screened for mediators downstream of TGF-β signaling to inhibit chondrocyte hypertrophy. …
Metadata
Title
TGF-β signaling induces SnoN to suppress BMP-induced hypertrophic maturation of chondrocytes
Authors
Shingo Maeda
Ichiro Kawamura
Yasuhiro Ishidou
Katsuyuki Imamura
Masahiro Yokouchi
Setsuro Komiya
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3642

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