Published in:
Open Access
01-12-2012 | Poster presentation
Cartilage-specific deletion of prar-gamma in mice results in early endochondral ossification defects and accelerated aging-dependent development of osteoarthritis
Authors:
Roxana Monemdjou, Faezeh Vasheghani, Hassan Fahmi, Gemma Perez, Meryem Blati, Noboru Taniguchi, Martin Lotz, René St-Arnaud, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Frank Beier, Mohit Kapoor
Published in:
Arthritis Research & Therapy
|
Special Issue 1/2012
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Excerpt
Long bones develop through a strict coordinated process of endochondral ossification within the growth plate resulting in the replacement of cartilage by bone and defect in this coordinated process may result in skeletal abnormalities such as dwarfism, kyposis and also age-related defects such as osteoarthritis (OA). PPARγ, a transcription factor, plays a key role in lipid homeostasis but its in vivo role in cartilage/bone development is unknown. Therefore, we determined the specific in vivo role of PPARγ in endochondral bone ossification, cartilage/bone development and in OA using cartilage-specific PPARγ knockout (KO) mice. …
