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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Oral presentation

Fcγ receptor targeting in RA

Authors: Toshiyuki Takai, Akira Nakamura, Akiko Tobinai, Shota Endo, Masanori Inui

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

The activation threshold of cells in the immune system is often tuned by cell surface molecules. Among these, Fc receptors expressed on various hematopoietic cells constitute critical elements for activating or down-modulating immune responses. …
Literature
1.
Nakamura A, Kubo T, Takai T: Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer. Adv Exp Med Biol. 2008, 640: 220-233. 10.1007/978-0-387-09789-3_17.CrossRefPubMed
2.
Nakamura A, Nukiwa T, Takai T: Deregulation of peripheral B-cell development in enhanced severity of collagen-induced arthritis in FcgammaRIIB-deficient mice. J Autoimmun. 2003, 20: 227-236. 10.1016/S0896-8411(03)00034-9.CrossRefPubMed
3.
Takai T: Roles of Fc receptors in autoimmunity. Nat Rev Immunol. 2002, 2: 580-592.PubMed
4.
Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumura K, Ono M, Ravetch JV, Takai T: Deletion of Fcγ receptor IIB renders H-2b mice susceptible to collagen-induced arthritis. J Exp Med. 1999, 189: 187-194. 10.1084/jem.189.1.187.PubMedCentralCrossRefPubMed
5.
Takai T, Ono M, Hikida M, Ohmori H, Ravetch JV: Augmented humoral and anaphylactic responses in FcγRII-deficient mice. Nature. 1996, 379: 346-349. 10.1038/379346a0.CrossRefPubMed
6.
Anthony RM, Kobayashi T, Wermeling F, Ravetch JV: Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway. Nature. 2011, 475: 110-113. 10.1038/nature10134.PubMedCentralCrossRefPubMed
Metadata
Title
Fcγ receptor targeting in RA
Authors
Toshiyuki Takai
Akira Nakamura
Akiko Tobinai
Shota Endo
Masanori Inui
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3572

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