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01-06-2011 | Review

Sjögren's syndrome: studying the disease in mice

Authors: Nicolas Delaleu, Cuong Q Nguyen, Ammon B Peck, Roland Jonsson

Published in: Arthritis Research & Therapy | Issue 3/2011

Abstract

Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the effect of experimental intervention. The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research.

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Title: Sjögren's syndrome: studying the disease in mice
Authors: Nicolas Delaleu
Cuong Q Nguyen
Ammon B Peck
Roland Jonsson
Publication date: 01-06-2011
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 3/2011
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar3313

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Sjögren's syndrome: studying the disease in mice

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