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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2010

01-04-2010 | Letter

DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies

Authors: Hidehiko Sugino, Hooi-Ming Lee, Norihiro Nishimoto

Published in: Arthritis Research & Therapy | Issue 2/2010

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Excerpt

In a recent interesting review, Alex Clarke and Timothy Vyse described the genetics of rheumatic disease [1]. In the past several years, genome-wide association studies (GWAS) have led to the identification of six high-risk rheumatoid arthritis (RA) susceptibility genes - namely, CD244, PADI4, SLC22A2, PTPN22, CTLA4, and STAT4 (summarized in [2]). In vitro studies using mutant alleles and cultured cells have revealed the individual upregulation of CD244, PADI4, SLC22A2, and PTPN22 [2‐6]; however, studies on the expression of RA susceptibility genes in RA patients are rare. We therefore investigated the expression of the above-mentioned six RA susceptibility genes in 112 RA patients using DNA microarray analysis. This study aims to clarify whether DNA microarray analysis and GWAS produce comparable results with respect to RA susceptibility genes. …
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Metadata
Title
DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies
Authors
Hidehiko Sugino
Hooi-Ming Lee
Norihiro Nishimoto
Publication date
01-04-2010
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2010
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2937

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