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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2009

01-10-2009 | Review

B cells in autoimmunity

Authors: Thomas Dörner, Annett M Jacobi, Peter E Lipsky

Published in: Arthritis Research & Therapy | Issue 5/2009

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Abstract

B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development as well as plasmablasts/plasma cells in immune regulation under normal and autoimmune conditions with particular emphasis on systemic lupus erythematosus. Based on preclinical and clinical data, B cells have emerged increasingly as both effector cells as well as cells with immunoregulatory potential.
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Metadata
Title
B cells in autoimmunity
Authors
Thomas Dörner
Annett M Jacobi
Peter E Lipsky
Publication date
01-10-2009
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2009
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2780

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