Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2009

01-10-2009 | Review

Lessons from animal models of arthritis over the past decade

Author: Wim B van den Berg

Published in: Arthritis Research & Therapy | Issue 5/2009

Login to get access

Abstract

This review summarizes the major developments in animal models of arthritis in the past decade. It focuses on novel transgenic models, addresses the involvement of cytokines and discusses novel findings in cartilage and bone erosion. It is clear that interest has been raised in the direct arthritogenic role of autoantibodies, apart from T cell involvement, and their interaction with cells through Fcgamma receptors. In addition, a role for IL-6 and IL-17 and Th17 cells seems apparent in most T cell-driven arthritis models, with environmental triggering through Toll-like receptors contributing to this process. Further insights into enzymes involved in cartilage proteoglycan loss in arthritis, as well as mediators regulating bone erosion and bone apposition, have been gained.
Literature
1.
Pearson CM: Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol (New York). 1956, 91: 95-101.CrossRef
2.
Van Eden W, Zee van der R, Prakken B: Heat shock proteins induce T cell regulation of chronic inflammation. Nat Rev Immunol Rev. 2005, 5: 318-330.CrossRef
3.
Kleinau S, Erlandsson H, Holmdahl R, Klareskog L: Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement. J Autoimmunity. 1991, 4: 871-880.CrossRef
4.
Wooley PH, Seibold JR, Whalen JD, Chapdelaine JM: Pristane induced arthritis. The immunologic and genetic features of an experimental murine model of autoimmune disease. Arthritis Rheum. 1989, 32: 1022-1030.CrossRefPubMed
5.
Holmdahl R, Lorentzen JC, Lu S, Olofsson P, Wester L, Holmberg J, Pettersson U: Arthritis induced in rats with nonimmunogenic adjuvants as models for RA. Immunol Rev. 2001, 184: 184-202.CrossRefPubMed
6.
Trentham DE, Townes AS, Kang AH: Autoimmunity to type II collagen: an experimental model of arthritis. J Exp Med. 1977, 146: 857-868.CrossRefPubMed
7.
Holmdahl R, Malmstrom V, Vuorio E: Autoimmune recognition of cartilage collagens. Ann Med. 1993, 25: 251-264.CrossRefPubMed
8.
Finnegan A, Mikecz K, Tao P, Glant TT: Proteoglycan (aggrecan)-induced arthritis in BALB/c mice is a Th1-type disease regulated by Th2 cytokines. J Immunol. 1999, 163: 5383-5390.PubMed
9.
Otto JM, Chandrasekeran R, Vermes C, Mikecz K, Finnegan A, Rickert SE, Enders JT, Glant TT: A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of RA. J Immunol. 2000, 165: 5278-5286.CrossRefPubMed
10.
Cromartie WJ, Craddock JG, Schwab JH, Anderle SK, Yang CH: Arthritis in rats after systemic injection of streptococcal cell walls. J Exp Med. 1977, 146: 1585-1602.CrossRefPubMed
11.
Joosten LA, Abdollahi-Roodsaz S, Heuvelmans-Jacobs M, Helsen MM, Bersselaar van den LA, Oppers-Walgreen B, Koenders MI, Berg van den WB: T cell dependence of chronic destructive murine arthritis induced by repeated local activation of TLR driven pathways. Crucial role of both IL-1b and IL-17. Arthritis Rheum. 2008, 58: 98-108.CrossRefPubMed
12.
Dumonde DC, Glynn LE: The production of arthritis in rabbits by an immunological reaction to fibrin. Brit J Exp Pathol. 1962, 43: 373-383.
13.
Berg Van den WB, Putte van de LBA, Zwarts WA, Joosten LA: Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. J Clin Invest. 1984, 74: 1850-1859.PubMedCentralCrossRefPubMed
14.
Koenders MI, Lubberts E, Oppers-Walgreen B, Bersselaar van den L, Helsen MM, Di Padova FE, Boots AM, Gram H, Joosten LA, Berg van den WB: Blocking of IL-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and IL-1. Am J Pathol. 2005, 167: 141-149.PubMedCentralCrossRefPubMed
15.
Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, Kitajima I, Nishioka K, Yamamoto K, Takeda T, Hatanaka M: Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science. 1991, 253: 1026-1028.CrossRefPubMed
16.
Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D: From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity. 1999, 10: 451-461.CrossRefPubMed
17.
Maccioni M, Zeder-Lutz G, Huang H, Ebel C, Gerber P, Hergueux J, Marchal P, Duchatelle V, Degott C, van Regenmortel M, Benoist C, Mathis D: Arthritogenic monoclonal antibodies from K/BxN mice. J Exp Med. 2002, 195: 1071-1077.PubMedCentralCrossRefPubMed
18.
Hata H, Sakaguchi N, Yoshitomi H, Iwakura Y, Sekikawa K, Azuma Y, Kanai C, Moriizumi E, Nomura T, Nakamura T, Sakaguchi S: Distinct contribution of IL-6, TNF-alpha, IL-1 and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice. J Clin Invest. 2004, 114: 582-588.PubMedCentralCrossRefPubMed
19.
Yoshitomi H, Sakaguchi N, Kobayashi K, Brown GD, Tagami T, Sakihama T, Hirota K, Tanaka S, Nomura T, Miki I, Gordon S, Akira S, Nakamura T, Sakaguchi S: A role for fungal (beta)-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med. 2005, 201: 949-960.PubMedCentralCrossRefPubMed
20.
Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, Kobayashi H, Park SJ, Saeki Y, Kitamura Y, Hirano T: A point mutation of Tyr-759 in IL-6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med. 2002, 196: 979-990.PubMedCentralCrossRefPubMed
21.
Sawa S, Kamimura D, Jin GH, Morikawa H, Kamon H, Nishihara M, Ishihara K, Murakami M, Hirano T: Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic prolifereation of CD4+ T cells. J Exp Med. 2006, 203: 1459-1470.PubMedCentralCrossRefPubMed
22.
Niki Y, Yamada H, Seki S, Kikuchi T, Takaishi H, Toyama Y, Fujikawa K, Tada N: Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic mice. J Clin Invest. 2001, 107: 1127-1135.PubMedCentralCrossRefPubMed
23.
Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, Ikuse T, Asano M, Iwakura Y: Development of chronic inflammatory arthropathy resembling RA in IL-1ra-deficient mice. J Exp Med. 2000, 191: 313-320.PubMedCentralCrossRefPubMed
24.
Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y: IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA. 2003, 100: 5986-5990.PubMedCentralCrossRefPubMed
25.
Horai R, Nakajima A, Habiro K, Kotani M, Nakae S, Matsuki T, Nambu A, Saijo S, Kotaki H, Sudo K, Okahara A, Tanioka H, Ikuse T, Ishii N, Schwartzberg PL, Abe R, Iwakura Y: TNFα is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest. 2004, 114: 1603-1611.PubMedCentralCrossRefPubMed
26.
Terato K, Hasty KA, Reife RA, Cremer MA, Kang AH, Stuart JM: Induction of arthritis with monoclonal antibodies to collagen. J Immunol. 1992, 148: 2103-2108.PubMed
27.
Nandakumar KS, Svensson L, Holmdahl R: Collagen type II specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex and genes. Am J Pathol. 2003, 163: 1827-1837.PubMedCentralCrossRefPubMed
28.
Blom AB, van Lent PLEM, van Vuuren H, Holthuysen AE, Jacobs C, Putte van de LB, Winkel van de JG, Berg van den WB: FcgammaR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA). Arthritis Res. 2000, 2: 489-503.PubMedCentralCrossRefPubMed
29.
Van Lent PLEM, Loo van de FAJ, Holthuysen AEM, Bersselaar van Den LA, Vermeer H, Berg van den WB: Major role for IL-1 but not for TNF in early cartilage damage in immune complex arthritis in mice. J Rheumatol. 1995, 22: 2250-2258.PubMed
30.
Nabbe KCAM, Boross P, Holthuysen AEM, Sloëtjes AW, Kolls JK, Verbeek S, van Lent PL, Berg van den WB: Joint inflammation and chondrocyte death become independent of Fcγ rIII by local overexpression of IFN-γ during immune complex mediated-arthritis. Arthritis Rheum. 2005, 52: 967-974.CrossRefPubMed
31.
Monach PA, Benoist C, Mathis D: The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease. Adv Immunol. 2004, 82: 217-248.CrossRefPubMed
32.
Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, Gravallese E, Mathis D, Benoist C: Critical roles for IL-1 and TNF in antibody induced arthritis. J Exp Med. 2002, 196: 77-85.PubMedCentralCrossRefPubMed
33.
Schubert D, Maier B, Morawietz L, Krenn V, Kamradt T: Immunization with glucose-6-phosphate isomerise induces T cell dependent peripheral polyarthritis in generally unaltered mice. J Immunol. 2004, 172: 4503-4509.CrossRefPubMed
34.
Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T: Crucial role of the IL-6/IL-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum. 2008, 58: 754-763.CrossRefPubMed
35.
Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, Holers VM: Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest. 2006, 116: 961-973.PubMedCentralCrossRefPubMed
36.
Hill JA, Bell DA, Brintnell W, Yue D, Wehrli B, Jevnikar AM, Lee DM, Hueber W, Robinson WH, Cairns E: Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. J Exp Med. 2008, 205: 967-979.PubMedCentralCrossRefPubMed
37.
Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engstrom A, Serre G, Burkhardt H, Thunnissen MMGM, Holmdahl R: Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009, 206: 449-462.PubMedCentralCrossRefPubMed
38.
Kidd BA, Ho PP, Sharpe O, Zhao X, Tomooka BH, Kanter JL, Steinman L, Robinson WH: Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination. Arthritis Res ther. 2008, 10: R119-PubMedCentralCrossRefPubMed
39.
Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumura K, Ono m, Ravetch JV, Takai T: Deletion of Fcgamma receptor IIB renders H-2b mice susceptible to collagen induced arthritis. J Exp Med. 1999, 189: 187-194.PubMedCentralCrossRefPubMed
40.
Tan SC, Mottram PL, Velde van de NC, Powell MS, Power D, Slocombe RF, Wicks IP, Campbell IK, McKenzie SE, Brooks M, Stevenson AW, Hogarth PM: Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice. Arthritis Rheum. 2005, 52: 3220-3229.CrossRef
41.
Pietersz GA, Mottram PL, Velde van de NC, Sardjono CT, Esparon S, Ramsland PA, Moloney G, Baell JB, McCarthy TD, Matthews BR, Powell MS, Hogarth PM: Inhibition of destructive autoimmune arthritis in FcgammaRIIa transgenic mice by small chemical entities. Immunol Cell Biol. 2009, 87: 3-12.CrossRefPubMed
42.
Boross P, Verbeek JS: The complex role of Fcgamma receptors in the pathology of arthritis. Springer Semin Immunopathol. 2006, 28: 339-350.CrossRefPubMed
43.
Hietala MA, Nandakumar KS, Persson L, Fahlen R, Holmdahl R, Pekna M: Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis. Eur J Immunol. 2004, 34: 1208-1216.CrossRefPubMed
44.
Banda NK, Takahashi K, Wood AK, Holers VM, Arend WP: Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway. J Immunol. 2007, 179: 4101-4109.CrossRefPubMed
45.
Katschke KJ, Helmy KY, Steffek M, Xi H, Yin J, Lee WP, Gribling P, Barck KH, Carano RA, Taylor RE, Rangell L, Diehl L, Hass PE, Wiesmann C, van Lookeren Campagne M: A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis. J Exp Med. 2007, 204: 1319-1325.PubMedCentralCrossRefPubMed
46.
Berg Van den WB: What we learn from arthritis models to benefit arthritis patients. Baillieres Best Pract Res Clin Rheumatol. 2000, 14: 599-616.CrossRefPubMed
47.
Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, Kollias G: Transgenic mice expressing human tumor necrosis factor: a predictive genetic model of arthritis. EMBO J. 1991, 13: 4025-4031.
48.
Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G: Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies. Immunity. 1999, 10: 387-398.CrossRefPubMed
49.
Kollias G, Douni E, Kassiotis G, Kontoyiannis D: On the role of TNF and receptors in models of multiorgan failure, RA, multiple sclerosis and inflammatory bowel disease. Immunol Rev. 1999, 169: 175-194.CrossRefPubMed
50.
Kassiotis G, Kollias G: Uncoupling the proinflammatory from the immunosuppressive properties of TNF at the p55 TNF receptor level: Implications for pathogenesis and therapy of autoimmune demyelination. J Exp Med. 2001, 193: 427-434.PubMedCentralCrossRefPubMed
51.
Zwerina J, Redlich K, Polzer K, Joosten L, Kronke G, Distler J, Hess A, Pundt N, Pap T, Hoffmann O, Gasse J, Scheinecker C, Smolen JS, Berg van den WB, Schett G: TNF-induced structural joint damage is mediated by IL-1. Proc Natl Acad Sci USA. 2007, 104: 11742-11747.PubMedCentralCrossRefPubMed
52.
Joosten LAB, Helsen MMA, Loo van de FAJ, Berg van den WB: Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFα, anti-IL-1α/β and IL-1ra. Arthritis Rheum. 1996, 39: 797-809.CrossRefPubMed
53.
Campbell IK, O'Donnell K, Lawlor KE, Wicks IP: Severe inflammatory arthritis and lymphadenopathy in the absence of TNF. J Clin Invest. 2001, 107: 1519-1527.PubMedCentralCrossRefPubMed
54.
Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AM, Walgreen B, di Padova FE, Nicklin MJ, Joosten LA, Berg van den WB: IL-1 drives pathogenic Th17 cells during spontaneous arthritis in IL-1ra deficient mice. Arthritis Rheum. 2008, 58: 3461-3470.CrossRefPubMed
55.
Broek Van den MF, Berg van den WB, Putte van de LBA, Severijnen AJ: Streptococcal cell wall induced arthritis and flare-up reactions in mice induced by homologous and heterologous cell walls. Am J Pathol. 1988, 133: 139-149.PubMedCentralPubMed
56.
Lubberts E, Schwarzenberger P, Huang W, Schurr JR, Peschon JJ, Berg van den WB, Kolls JK: Requirement of IL-17 receptor signaling in resident synoviocytes for development of full blown destructive arthritis. J Immunol. 2005, 175: 3360-3368.CrossRefPubMed
57.
Joosten LA, Netea MG, Kim SH, Yoon DY, Oppers-Walgreen B, Radstake TR, Barrera P, Loo van de FA, Dinarello CA, Berg van den WB: IL-32 a proinflammatory cytokine in RA. Proc Natl Acad Sci USA. 2006, 103: 3298-3303.PubMedCentralCrossRefPubMed
58.
De Hooge AS, Loo van de FA, Arntz OJ, Berg van den WB: Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis. Am J Pathol. 2000, 157: 2081-2091.PubMedCentralCrossRefPubMed
59.
Miossec P: IL-17 in fashion, at last: ten years after its description, its cellular source has been identified. Arthritis Rheum. 2007, 56: 2111-2115.CrossRefPubMed
60.
Bettelli E, Oukka M, Kuchroo VK: Th17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007, 8: 345-350.CrossRefPubMed
61.
Fujimoto M, Serada S, Mihara M, Uchiyama Y, Yoshida H, Koike N, Ohsugi Y, Nishikawa T, Ripley B, Kimura A, Kishimoto T, Naka T: IL-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum. 2008, 58: 3710-3719.CrossRefPubMed
62.
Lubberts E, Bersselaar van den L, Oppers Walgreen B, Scharzenberger P, Coenen-de Roo CJ, Kolls JK, Joosten LA, Berg van den WB: IL-17 promotes bone erosion in murine collagen induced arthritis through loss of RANKL/OPG balance. J Immunol. 2003, 170: 2655-2662.CrossRefPubMed
63.
Koenders MI, Lubberts E, Loo van de FAJ, Oppers-Walgreen B, Bersselaar van den L, Helsen MM, Kolls JK, Di Padova FE, Joosten LA, Berg van den WB: Interleukin-17 acts independently of TNF-α under arthritic conditions. J Immunol. 2006, 176: 6262-6269.CrossRefPubMed
64.
Lubberts E, Koenders MI, Oppers Walgreen B, Bersselaar van den L, Coenen-de Roo CJ, Joosten LA, Berg van den WB: Treatment with a neutralizing anti-murine IL-17 antibody after the onset of collagen arthritis reduces joint inflammation, cartilage destruction and bone erosion. Arthritis Rheum. 2004, 50: 650-659.CrossRefPubMed
65.
Doodes PD, Cao Y, Hamel KM, Wang Y, Farkas B, Iwakura Y, Finnegan A: Development of proteoglycan induced arthritis is independent of IL-17. J Immunol. 2008, 181: 329-337.PubMedCentralCrossRefPubMed
66.
Luger D, Silver PB, Tang J, Cua D, Chen Z, Iwakura Y, Bowman EP, Sgambellone NM, Chan CC, Caspi RR: Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008, 205: 799-810.PubMedCentralCrossRefPubMed
67.
Abdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF, Radstake TR, Heuvelmans-Jacobs M, Akira S, Nicklin MJ, Ribeiro-Dias F, Berg van den WB: Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest. 2008, 118: 205-216.PubMedCentralCrossRefPubMed
68.
Abdollahi-Roodsaz S, Joosten LA, Roelofs MF, Radstake TR, Matera G, Popa C, Meer van der JW, Netea MG, Berg van den WB: Inhibition of TLR4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum. 2007, 56: 2957-2967.CrossRefPubMed
69.
Choe JY, Crain B, Wu SR, Corr M: IL-1 receptor dependence of serum transferred arthritis can be prevented by TLR4 signaling. J Exp Med. 2003, 197: 537-542.PubMedCentralCrossRefPubMed
70.
van Lent PL, Hoek van den AE, Bersselaar van den LA, Ende van de M, Dijkstra CD, van Rooijen N, Putte van de LB, Berg van den WB: In vivo role of phagocytic synovial lining cells in onset of experimental arthritis. Am J Pathol. 1993, 143: 1226-1237.PubMedCentralPubMed
71.
Lee DM, Kiener HP, Agarwal SK, Brenner MB: Cadherin-11 in synovial lining formation and pathology in arthritis. Science. 2007, 315: 1006-1010.CrossRefPubMed
72.
Nigrovic PA, Binstadt BA, Monach PA, Johnsen A, Gurish M, Iwakura Y, Benoist C, Mathis D, Lee DM: Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1. Proc Natl Acad Sci USA. 2007, 104: 2325-2330.PubMedCentralCrossRefPubMed
73.
Berg Van den WB: Uncoupling of inflammatory and destructive mechanisms in arthritis. Semin Arthritis Rheum. 2001, 30 (Suppl 2): 7-16.CrossRefPubMed
74.
Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ: ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature. 2005, 434: 648-652.CrossRefPubMed
75.
Little CB, Meeker CT, Golub SB, Lawlor KE, Farmer PJ, Smith SM, Fosang AJ: Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest. 2007, 117: 1627-1636.PubMedCentralCrossRefPubMed
76.
Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, Flannery CR, Peluso D, Kanki K, Yang Z, Majumdar MK, Morris EA: Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 2005, 434: 644-648.CrossRefPubMed
77.
Van Meurs JBJ, van Lent PLEM, Singer II, Bayne EK, Loo van de FA, Berg van den WB: IL-1ra prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis. Arthritis Rheum. 1998, 41: 647-656.CrossRefPubMed
78.
Nabbe KC, van lent PL, Holthuysen AE, Kolls JK, Verbeek S, Berg van den WB: FcgammaRI upregulation induced by local adenoviral mediated IFNg production aggravates chondrocyte death during immune complex mediated arthritis. Am J Pathol. 2003, 163: 743-752.PubMedCentralCrossRefPubMed
79.
van Lent PL, Grevers L, Lubberts E, de Vries TJ, Nabbe KC, Verbeek S, Oppers B, Sloetjes A, Blom AB, Berg van den WB: FcgR mediate cartilage but not bone destruction in murine AIA: uncoupling of cartilage damage from bone erosion and joint inflammation. Arthritis Rheum. 2006, 54: 3868-3877.CrossRefPubMed
80.
Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM: Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 1999, 402: 304-309.CrossRefPubMed
81.
Lubberts E, Joosten LAB, Chabaud M, Bersselaar van Den L, Oppers B, Coenen-De Roo CJ, Richards CD, Miossec P, Berg van Den WB: IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion. J Clin Invest. 2000, 105: 1697-1710.PubMedCentralCrossRefPubMed
82.
Pettit AR, Ji H, von Stechow D, Müller R, Goldring SR, Choi Y, Benoist C, Gravallese EM: TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol. 2001, 159: 1689-1699.PubMedCentralCrossRefPubMed
83.
Redlich K, Hayer S, Ricci R, David JP, Tohidast-Akrad M, Kollias G, Steiner G, Smolen JS, Wagner EF, Schett G: Osteoclasts are essential for TNFα-mediated joint destruction. J Clin Invest. 2002, 110: 1419-1427.PubMedCentralCrossRefPubMed
84.
Redlich K, Gortz B, Hayer S, Zwerina J, Doerr N, Kostenuik P, Bergmeister H, Kollias G, Steiner G, Smolen JS, Schett G: Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-TNF in combination with osteoprotegerin or parathyroid hormone in TNF-mediated arthritis. Am J Pathol. 2004, 164: 543-555.PubMedCentralCrossRefPubMed
85.
Zwerina J, Hayer S, Tohidast-Akrad M, Bergmeister H, Redlich K, Feige U, Dunstan C, Kollias G, Steiner G, Smolen J, Schett G: Single and combined inhibition of TNF, IL-1 and RANKL pathways in TNF-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction. Arthritis Rheum. 2004, 50: 277-290.CrossRefPubMed
86.
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, Heide van der D, Landewe R, Lacey D, Richards WG, Schett G: Dickkopf-1 is a master regulator of joint remodeling. Nat Med. 2007, 13: 156-163.CrossRefPubMed
87.
Scharstuhl A, Glansbeek HL, van Beuningen HM, Vitters EL, Kraan van der PM, Berg van den WB: Inhibition of endogenous TGFb during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. J Immunol. 2002, 169: 507-514.CrossRefPubMed
Metadata
Title
Lessons from animal models of arthritis over the past decade
Author
Wim B van den Berg
Publication date
01-10-2009
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2009
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2803

Other articles of this Issue 5/2009

Arthritis Research & Therapy 5/2009 Go to the issue

Research article

Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4

Research article

Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis

Research article

The role of patient expectations in predicting outcome after total knee arthroplasty

Editorial

Measuring metacarpal cortical bone by digital x-ray radiogrammetry: a step forward?

Research article

Synovial tissues concentrate secreted APRIL

Review

Developments in the scientific understanding of rheumatoid arthritis
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits