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Open Access 01-02-2009 | Research article

No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis

Authors: Olivier Jaen, Elisabeth Petit-Teixeira, Holger Kirsten, Peter Ahnert, Luca Semerano, Céline Pierlot, Francois Cornelis, Marie-Christophe Boissier, Geraldine Falgarone, the European Consortium on Rheumatoid Arthritis Families

Published in: Arthritis Research & Therapy | Issue 1/2009

Abstract

Introduction

The objective was to study the potential genetic contribution of Toll-like receptor (TLR) genes in rheumatoid arthritis (RA). TLRs bind to pathogen-associated molecular patterns, and TLR genes influence both proinflammatory cytokine production and autoimmune responses. Host–pathogen interactions are involved in RA physiopathology.

Methods

We tested SNPs of five TLR genes (TLR9, TLR2, TLR6, TLR1, and TLR4) in a cohort of 100 French families with RA. Genotypes were analyzed using the transmission disequilibrium test. As TLR2, TLR6, and TLR1 are located on chromosome 4, we determined the haplotype relative risk. Analyses were performed in subgroups defined by status for rheumatoid factor, anti-cyclic citrullinated peptide autoantibodies, and erosions.

Results

We found no disequilibrium in allele transmission for any of the SNPs of the five TLR genes. In subgroup analyses, no associations were detected linking TLR9, TLR2, or TLR9/TLR2 to rheumatoid factor, anti-cyclic citrullinated peptide autoantibodies, or erosions. Haplotype analysis of the polymorphisms showed no haplotype associations in any of the subgroups.

Conclusions

We found no evidence of major effects of TLR gene polymorphisms in RA, although we tested different TLR phenotypes. Moreover, no associations were noted with autoantibody production or erosions.

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Title: No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis
Authors: Olivier Jaen
Elisabeth Petit-Teixeira
Holger Kirsten
Peter Ahnert
Luca Semerano
Céline Pierlot
Francois Cornelis
Marie-Christophe Boissier
Geraldine Falgarone
the European Consortium on Rheumatoid Arthritis Families
Publication date: 01-02-2009
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 1/2009
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2589

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