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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 6/2007

01-12-2006 | Review

What is MRI bone oedema in rheumatoid arthritis and why does it matter?

Authors: Fiona M McQueen, Benedikt Ostendorf

Published in: Arthritis Research & Therapy | Issue 6/2007

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Abstract

MRI bone oedema occurs in various forms of inflammatory and non-inflammatory arthritis and probably represents a cellular infiltrate within bone. It is common in early rheumatoid arthritis and is associated with erosive progression and poor functional outcome. Histopathological studies suggest that a cellular infiltrate comprising lymphocytes and osteoclasts may be detected in subchondral bone and could mediate the development of erosions from the marrow towards the joint surface. There is emerging evidence from animal models that such an infiltrate corresponds with MRI bone oedema, pointing towards the bone marrow as a site for important pathology driving joint damage in rheumatoid arthritis.
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Metadata
Title
What is MRI bone oedema in rheumatoid arthritis and why does it matter?
Authors
Fiona M McQueen
Benedikt Ostendorf
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 6/2007
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2075

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