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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2004

01-09-2004 | Poster presentation

Influence of corticosteroids on C-reactive protein in patients with rheumatoid arthritis

Authors: E Mysler, C Psioni, P Tate, G Tate

Published in: Arthritis Research & Therapy | Special Issue 3/2004

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Excerpt

C-reactive protein (CRP) is an acute phase reactant. It is usually increased in rheumatoid arthritis (RA) patients when disease is most active. These patients would be expected to participate in clinical trials, high CRP being a frequent requirement for inclusion. At the same time this group of patients is usually treated with moderate to high dose steroids. Steroids have the potential to decrease CRP without modifying disease progression. It has been our clinical observation that very active patients are probably not influenced very much by steroids, but patients with moderate disease activity who use low doses of steroids have their CRP lowered or suppressed. …
Literature
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Thompson PW, Silman AJ, Kirwan JR, Currey HL: Articular indices of joint inflammation in rheumatoid arthritis. Correlation with the acute-phase response. Arthritis Rheum. 1987, 30: 618-623.CrossRefPubMed
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Paulus HE, Ramos B, Wong WK, Ahmed A, Bulpitt K, Park G, Sterz M, Clements P: Equivalence of the acute phase reactants C-reactive protein, plasma viscosity, and westergren erythrocyte sedimentation rate when used to calculate American College of Rheumatology 20% improvement criteria or the disease activity score in patients with early rheumatoid arthritis. J Rheumatol. 1999, 26: 2324-2331.PubMed
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Felson DT, Anderson JJ, Boers M, et al: The American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 1995, 38: 727-735.CrossRefPubMed
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McConkey B, Davies P, Crockson RA, Crockson AP, Butler M, Constable TJ, Amos RS: Effects of gold, dapsone, and prednisone on serum C-reactive protein and haptoglobin and the erythrocyte sedimentation rate in rheumatoid arthritis. Ann Rheum Dis. 1979, 38: 141-144.CrossRefPubMedCentralPubMed
Metadata
Title
Influence of corticosteroids on C-reactive protein in patients with rheumatoid arthritis
Authors
E Mysler
C Psioni
P Tate
G Tate
Publication date
01-09-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 3/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1392

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