Published in:
01-09-2004 | Poster presentation
Protective role of interferon gamma in murine antigen-induced arthritis
Authors:
M Hückel, I Irmler, J Simon, A Radbruch, A Scheffold, R Bräuer
Published in:
Arthritis Research & Therapy
|
Special Issue 3/2004
Login to get access
Excerpt
In human rheumatoid arthritis interactions of immune cells with resident cells, especially synovial fibroblasts, play a crucial role in the perpetuation of inflammatory and destructive processes in affected joints. Apart from macrophages, Th cells are predominant in cell infiltrates, and Th cell responses are specified as Th1 type. As interferon gamma (IFN-γ) secreting Th1 cells are suspected to promote autoimmune diseases, there is the notion that a shift of a Th1 response towards a Th2 response might ameliorate arthritis. However, in different models and therapy studies conflicting results are described. Thus, we investigated the role of IFN-γ in murine antigen-induced arthritis (AIA), a model with homologies to human rheumatoid arthritis in terms of histopathology, chronicity and responses to several immunomodulatory drugs. …
