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Published in: Arthritis Research & Therapy 6/2000

Open Access 01-09-2000 | Research article

Mesenchymal precursor cells in the blood of normal individuals

Authors: Nathan J Zvaifler, Lilla Marinova-Mutafchieva, Gill Adams, Christopher J Edwards, Jill Moss, Jan A Burger, Ravinder N Maini

Published in: Arthritis Research & Therapy | Issue 6/2000

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Statement of findings

Mesenchymal precursor cells found in the blood (BMPCs) of normal persons adhere to plastic and glass and proliferate logarithmically in DMEM-20% fetal calf serum (FCS) without growth factors. They form cells with fibroblast-like and stromal morphology, which is not affected by eliminating CD34, CD3, or CD14 cells. Osteogenic supplements (dexamethasone, ascorbic acid, and β-glycerophosphate) added to the culture inhibited fibroblast formation, and BMPCs assumed the cuboidal shape of osteoblasts. After 5 days in supplemented medium, the elutriated cells displayed alkaline phosphatase (AP), and the addition of bone morphogenetic protein (BMP)2 (1 ng) doubled AP production (P < 0.04). Two weeks later, 30% of the cells were very large and reacted with anti-osteocalcin antibody. The same cultures also contained sudanophlic adipocytes and multinucleated giant cells that stained for tartrate-resistant acid phosphatase (TRAP) and vitronectin receptors. Cultured BMPCs immunostain with antibodies to vimentin, type I collagen, and BMP receptors, heterodimeric structures expressed on mesenchymal lineage cells. In addition, BMPCs stain with anti-CD105 (endoglin), a putative marker for bone-marrow mesenchymal stem cells (MSCs).
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Metadata
Title
Mesenchymal precursor cells in the blood of normal individuals
Authors
Nathan J Zvaifler
Lilla Marinova-Mutafchieva
Gill Adams
Christopher J Edwards
Jill Moss
Jan A Burger
Ravinder N Maini
Publication date
01-09-2000
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 6/2000
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar130

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