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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 6/2000

Open Access 01-09-2000 | Research article

Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis

Authors: Roberto Salvi, Veronique Péclat, Alexander So, Nathalie Busso

Published in: Arthritis Research & Therapy | Issue 6/2000

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Statement of findings

We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue factor, tissue factor pathway inhibitor, urokinase plasminogen activator, and plasminogen activator inhibitor 1, as well as thrombin receptor. The observed pattern of gene expression tended to favor procoagulant activity, and this pattern was confirmed by functional assays. These alterations would account for persistence of fibrin within the inflamed joint, as is seen in rheumatoid arthritis.
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Metadata
Title
Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
Authors
Roberto Salvi
Veronique Péclat
Alexander So
Nathalie Busso
Publication date
01-09-2000
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 6/2000
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar132

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