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Open Access 01-12-2013 | Review

Nuclear imaging of inflammation: homing-associated molecules as targets

Authors: Anu Autio, Sirpa Jalkanen, Anne Roivainen

Published in: EJNMMI Research | Issue 1/2013

Abstract

The golden standard in nuclear medicine imaging of inflammation is the use of autologous radiolabeled leukocytes. Although their diagnostic accuracy is precise, the preparation of the leukocytes is both laborious and potentially hazardous for laboratory personnel. Molecules involved in leukocyte migration (homing-associated molecules) could serve as targets for the development of imaging agents for inflammation. An excellent target would be a molecule that is absent or expressed at low levels in healthy tissues, but is present or upregulated at the sites of inflammation. In this paper, we will review the literature concerning the use of homing-associated molecules as imaging targets. We will especially concentrate on vascular adhesion protein-1 due to the promising results regarding its use as a target for the imaging of inflammation.

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Title: Nuclear imaging of inflammation: homing-associated molecules as targets
Authors: Anu Autio
Sirpa Jalkanen
Anne Roivainen
Publication date: 01-12-2013
Publisher: Springer Berlin Heidelberg
Published in: EJNMMI Research / Issue 1/2013
Electronic ISSN: 2191-219X
DOI: https://doi.org/10.1186/2191-219X-3-1

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Nuclear imaging of inflammation: homing-associated molecules as targets

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