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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-07-2006 | Original paper

α_vβ₃-integrin imaging: a new approach to characterise angiogenesis?

Author: Roland Haubner

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2006

Abstract

Overview

The field of angiogenesis research is one of the most rapidly growing biomedical disciplines. Great efforts are being made to develop anti-angiogenesis drugs for treatment of cancer as well as non-oncological diseases. Thus, imaging techniques allowing non-invasive monitoring of corresponding molecular processes will be of great interest. One target structure involved in the angiogenic process is the integrin α_vβ₃, which mediates the migration of activated endothelial cells during vessel formation.

Materials and methods

A variety of radiolabelled RGD peptides have been introduced for monitoring of α_vβ₃ expression using nuclear medicine tracer techniques.

Objectives

This review discusses tracer development and highlights some strategies for tracer optimisation. It summarises the preclinical and clinical data and discusses the potential of this class of tracer to characterise angiogenesis.

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Title: αvβ3-integrin imaging: a new approach to characterise angiogenesis?
Author: Roland Haubner
Publication date: 01-07-2006
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2006
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-006-0136-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

α_vβ₃-integrin imaging: a new approach to characterise angiogenesis?

Abstract

Overview

Materials and methods

Objectives

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Overview

Materials and methods

Objectives

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