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Published in: Clinical Sarcoma Research 1/2013

Open Access 01-12-2013 | Case Report

Dermatofibrosarcoma protuberans (DFSP) successfully treated with sorafenib: case report

Authors: Francois G Kamar, Victor F Kairouz, Alain N Sabri

Published in: Clinical Sarcoma Research | Issue 1/2013

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Abstract

DFSP is a locally invasive, slow-growing tumor of the subcutaneous tissue that rarely metastasizes but recurs frequently after surgical excision. We report herein a case of highly recurrent, locally invasive DFSP that failed both postoperative radiation therapy and complete trial of Imatinib, but was successfully treated with Sorafenib, which showed unprecedented response.
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Literature
1.
go back to reference Darier J: Dermatofibromes progressifs et recidivants ou fibrosarcomes de la peu. Ann Dermatol Syphiligr (Paris). 1924, 5: 542-562. Darier J: Dermatofibromes progressifs et recidivants ou fibrosarcomes de la peu. Ann Dermatol Syphiligr (Paris). 1924, 5: 542-562.
2.
go back to reference McLoughlin PM, Girach M, Wood GA: Dermatofibrosarcoma protuberans of the scalp. Br J Oral Maxillofac Surg. 1992, 30: 401-403. 10.1016/0266-4356(92)90211-ZCrossRefPubMed McLoughlin PM, Girach M, Wood GA: Dermatofibrosarcoma protuberans of the scalp. Br J Oral Maxillofac Surg. 1992, 30: 401-403. 10.1016/0266-4356(92)90211-ZCrossRefPubMed
3.
go back to reference Mentzel T, Beham A, Katenkamp D, Dei Tos AP, Fletcher CD: Fibrosarcomatous ("high-grade") dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance. Am J Surg Pathol. 1998, 22: 576-587. 10.1097/00000478-199805000-00009CrossRefPubMed Mentzel T, Beham A, Katenkamp D, Dei Tos AP, Fletcher CD: Fibrosarcomatous ("high-grade") dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance. Am J Surg Pathol. 1998, 22: 576-587. 10.1097/00000478-199805000-00009CrossRefPubMed
4.
go back to reference Bowne WB, Antonescu CR, Leung DH: Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution. Cancer. 2000, 88: 2711-2720. 10.1002/1097-0142(20000615)88:12<2711::AID-CNCR9>3.0.CO;2-MCrossRefPubMed Bowne WB, Antonescu CR, Leung DH: Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution. Cancer. 2000, 88: 2711-2720. 10.1002/1097-0142(20000615)88:12<2711::AID-CNCR9>3.0.CO;2-MCrossRefPubMed
5.
go back to reference Miller SJ, Alam M, Andersen J: Dermatofibrosarcoma protuberans. J Natl Compr Canc Netw. 2007, 5: 550-555.PubMed Miller SJ, Alam M, Andersen J: Dermatofibrosarcoma protuberans. J Natl Compr Canc Netw. 2007, 5: 550-555.PubMed
6.
go back to reference McArthur GA: Dermatofibrosarcoma protuberans: a surgical disease with a molecular savior. Curr Opin Oncol. 2006, 18: 341-346. 10.1097/01.cco.0000228739.62756.dfCrossRefPubMed McArthur GA: Dermatofibrosarcoma protuberans: a surgical disease with a molecular savior. Curr Opin Oncol. 2006, 18: 341-346. 10.1097/01.cco.0000228739.62756.dfCrossRefPubMed
7.
go back to reference Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR: Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer. 2002, 100: 623-626. 10.1002/ijc.10535CrossRefPubMed Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR: Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer. 2002, 100: 623-626. 10.1002/ijc.10535CrossRefPubMed
8.
go back to reference Rubin BP, Schuetze SM, Eary JF: Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol. 2002, 20: 3586-3591. 10.1200/JCO.2002.01.027CrossRefPubMed Rubin BP, Schuetze SM, Eary JF: Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol. 2002, 20: 3586-3591. 10.1200/JCO.2002.01.027CrossRefPubMed
9.
go back to reference Mizutani K, Tamada Y, Hara K: Imatinib mesylate inhibits the growth of metastatic lung lesions in a patient with dermatofibrosarcoma protuberans. Br J Dermatol. 2004, 151: 235-237. 10.1111/j.1365-2133.2004.06024.xCrossRefPubMed Mizutani K, Tamada Y, Hara K: Imatinib mesylate inhibits the growth of metastatic lung lesions in a patient with dermatofibrosarcoma protuberans. Br J Dermatol. 2004, 151: 235-237. 10.1111/j.1365-2133.2004.06024.xCrossRefPubMed
10.
go back to reference Labropoulos SV, Fletcher JA, Oliveira AM, Papadopoulos S, Razis ED: Sustained complete remission of metastatic dermatofibrosarcoma protuberans with imatinib mesylate. Anticancer Drugs. 2005, 16: 461-466. 10.1097/00001813-200504000-00014CrossRefPubMed Labropoulos SV, Fletcher JA, Oliveira AM, Papadopoulos S, Razis ED: Sustained complete remission of metastatic dermatofibrosarcoma protuberans with imatinib mesylate. Anticancer Drugs. 2005, 16: 461-466. 10.1097/00001813-200504000-00014CrossRefPubMed
11.
go back to reference Price VE, Fletcher JA, Zielenska M: Imatinib mesylate: an attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans. Pediatr Blood Cancer. 2005, 44: 511-515. 10.1002/pbc.20249CrossRefPubMed Price VE, Fletcher JA, Zielenska M: Imatinib mesylate: an attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans. Pediatr Blood Cancer. 2005, 44: 511-515. 10.1002/pbc.20249CrossRefPubMed
12.
go back to reference Abrams TA, Schuetze SM: Targeted therapy for dermatofibrosarcoma protuberans. Curr Oncol Rep. 2006, 8: 291-296. 10.1007/s11912-006-0035-3CrossRefPubMed Abrams TA, Schuetze SM: Targeted therapy for dermatofibrosarcoma protuberans. Curr Oncol Rep. 2006, 8: 291-296. 10.1007/s11912-006-0035-3CrossRefPubMed
13.
go back to reference Kasper B, Lossignol D, Gil T, Flamen P, De Saint AN, Awada A: Imatinib mesylate in a patient with metastatic disease originating from a dermatofibrosarcoma protuberans of the scalp. Anticancer Drugs. 2006, 17: 1223-1225. 10.1097/01.cad.0000231486.94191.65CrossRefPubMed Kasper B, Lossignol D, Gil T, Flamen P, De Saint AN, Awada A: Imatinib mesylate in a patient with metastatic disease originating from a dermatofibrosarcoma protuberans of the scalp. Anticancer Drugs. 2006, 17: 1223-1225. 10.1097/01.cad.0000231486.94191.65CrossRefPubMed
14.
go back to reference Mehrany K, Swanson NA, Heinrich MC: Dermatofibrosarcoma protuberans: a partial response to imatinib therapy. Dermatol Surg. 2006, 32: 456-459. 10.1111/j.1524-4725.2006.32090.xPubMed Mehrany K, Swanson NA, Heinrich MC: Dermatofibrosarcoma protuberans: a partial response to imatinib therapy. Dermatol Surg. 2006, 32: 456-459. 10.1111/j.1524-4725.2006.32090.xPubMed
15.
go back to reference Savoia P, Ortoncelli M, Quaglino P, Bernengo MG: Imatinib mesylate in the treatment of a large unresectable dermatofibrosarcoma protuberans: a case study. Dermatol Surg. 2006, 32: 1097-1102. 10.1111/j.1524-4725.2006.32236.xPubMed Savoia P, Ortoncelli M, Quaglino P, Bernengo MG: Imatinib mesylate in the treatment of a large unresectable dermatofibrosarcoma protuberans: a case study. Dermatol Surg. 2006, 32: 1097-1102. 10.1111/j.1524-4725.2006.32236.xPubMed
16.
go back to reference McArthur GA: Molecular targeting of dermatofibrosarcoma protuberans: a new approach to a surgical disease. J Natl Compr Canc Netw. 2007, 5: 557-562.PubMed McArthur GA: Molecular targeting of dermatofibrosarcoma protuberans: a new approach to a surgical disease. J Natl Compr Canc Netw. 2007, 5: 557-562.PubMed
17.
go back to reference Ugurel S: Targeted therapy of dermatofibrosarcoma with imatinib. J Dtsch Dermatol Ges. 2007, 5: 261-CrossRefPubMed Ugurel S: Targeted therapy of dermatofibrosarcoma with imatinib. J Dtsch Dermatol Ges. 2007, 5: 261-CrossRefPubMed
18.
go back to reference Brabant B, Revol M, Vergote T, Servant JM, Banzet P: Dermatofibrosarcoma protuberans of the chest and the shoulder: wide and deep excisions with immediate reconstruction. Plast Reconstr Surg. 1993, 92: 459-462. 10.1097/00006534-199309000-00012CrossRefPubMed Brabant B, Revol M, Vergote T, Servant JM, Banzet P: Dermatofibrosarcoma protuberans of the chest and the shoulder: wide and deep excisions with immediate reconstruction. Plast Reconstr Surg. 1993, 92: 459-462. 10.1097/00006534-199309000-00012CrossRefPubMed
19.
go back to reference Arnaud EJ, Perrault M, Revol M, Servant JM, Banzet P: Surgical treatment of dermatofibrosarcoma protuberans. Plast Reconstr Surg. 1997, 100: 884-895. 10.1097/00006534-199709001-00009CrossRefPubMed Arnaud EJ, Perrault M, Revol M, Servant JM, Banzet P: Surgical treatment of dermatofibrosarcoma protuberans. Plast Reconstr Surg. 1997, 100: 884-895. 10.1097/00006534-199709001-00009CrossRefPubMed
20.
go back to reference Mendenhall WM, Zlotecki RA, Scarborough MT: Dermatofibrosarcoma protuberans. Cancer. 2004, 101: 2503-2508. 10.1002/cncr.20678CrossRefPubMed Mendenhall WM, Zlotecki RA, Scarborough MT: Dermatofibrosarcoma protuberans. Cancer. 2004, 101: 2503-2508. 10.1002/cncr.20678CrossRefPubMed
21.
go back to reference Kransdorf MJ: Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol. 1995, 164: 129-134. 10.2214/ajr.164.1.7998525CrossRefPubMed Kransdorf MJ: Malignant soft-tissue tumors in a large referral population: distribution of diagnoses by age, sex, and location. AJR Am J Roentgenol. 1995, 164: 129-134. 10.2214/ajr.164.1.7998525CrossRefPubMed
22.
go back to reference Chang CK, Jacobs IA, Salti GI: Outcomes of surgery for dermatofibrosarcoma protuberans. Eur J Surg Oncol. 2004, 30: 341-345. 10.1016/j.ejso.2003.12.005CrossRefPubMed Chang CK, Jacobs IA, Salti GI: Outcomes of surgery for dermatofibrosarcoma protuberans. Eur J Surg Oncol. 2004, 30: 341-345. 10.1016/j.ejso.2003.12.005CrossRefPubMed
23.
go back to reference Gloster HM: Dermatofibrosarcoma protuberans. J Am Acad Dermatol. 1996, 35: 355-374. quiz 375–356, 10.1016/S0190-9622(96)90597-6CrossRefPubMed Gloster HM: Dermatofibrosarcoma protuberans. J Am Acad Dermatol. 1996, 35: 355-374. quiz 375–356, 10.1016/S0190-9622(96)90597-6CrossRefPubMed
24.
go back to reference Criscione VD, Weinstock MA: Descriptive epidemiology of dermatofibrosarcoma protuberans in the united states, 1973 to 2002. J Am Acad Dermatol. 2007, 56: 968-973. 10.1016/j.jaad.2006.09.006CrossRefPubMed Criscione VD, Weinstock MA: Descriptive epidemiology of dermatofibrosarcoma protuberans in the united states, 1973 to 2002. J Am Acad Dermatol. 2007, 56: 968-973. 10.1016/j.jaad.2006.09.006CrossRefPubMed
25.
go back to reference Barnes L, Coleman JA, Johnson JT: Dermatofibrosarcoma protuberans of the head and neck. Arch Otolaryngol. 1984, 110: 398-404. 10.1001/archotol.1984.00800320052012CrossRefPubMed Barnes L, Coleman JA, Johnson JT: Dermatofibrosarcoma protuberans of the head and neck. Arch Otolaryngol. 1984, 110: 398-404. 10.1001/archotol.1984.00800320052012CrossRefPubMed
26.
go back to reference Taylor HB, Helwig EB: Dermatofibrosarcoma protuberans. A study of 115 cases. Cancer. 1962, 15: 717-725. 10.1002/1097-0142(196207/08)15:4<717::AID-CNCR2820150405>3.0.CO;2-2CrossRefPubMed Taylor HB, Helwig EB: Dermatofibrosarcoma protuberans. A study of 115 cases. Cancer. 1962, 15: 717-725. 10.1002/1097-0142(196207/08)15:4<717::AID-CNCR2820150405>3.0.CO;2-2CrossRefPubMed
27.
go back to reference Stojadinovic A, Karpoff HM, Antonescu CR: Dermatofibrosarcoma protuberans of the head and neck. Ann Surg Oncol. 2000, 7: 696-704. 10.1007/s10434-000-0696-3CrossRefPubMed Stojadinovic A, Karpoff HM, Antonescu CR: Dermatofibrosarcoma protuberans of the head and neck. Ann Surg Oncol. 2000, 7: 696-704. 10.1007/s10434-000-0696-3CrossRefPubMed
28.
go back to reference Fiore M, Miceli R, Mussi C: Dermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rate. J Clin Oncol. 2005, 23: 7669-7675. 10.1200/JCO.2005.02.5122CrossRefPubMed Fiore M, Miceli R, Mussi C: Dermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rate. J Clin Oncol. 2005, 23: 7669-7675. 10.1200/JCO.2005.02.5122CrossRefPubMed
29.
go back to reference Wacker J, Khan-Durani B, Hartschuh W: Modified mohs micrographic surgery in the therapy of dermatofibrosarcoma protuberans: analysis of 22 patients. Ann Surg Oncol. 2004, 11: 438-444. 10.1245/ASO.2004.06.014CrossRefPubMed Wacker J, Khan-Durani B, Hartschuh W: Modified mohs micrographic surgery in the therapy of dermatofibrosarcoma protuberans: analysis of 22 patients. Ann Surg Oncol. 2004, 11: 438-444. 10.1245/ASO.2004.06.014CrossRefPubMed
30.
go back to reference Lemm D, Mugge LO, Mentzel T, Hoffken K: Current treatment options in dermatofibrosarcoma protuberans. J Cancer Res Clin Oncol. 2009, 135: 653-665. 10.1007/s00432-009-0550-3CrossRefPubMed Lemm D, Mugge LO, Mentzel T, Hoffken K: Current treatment options in dermatofibrosarcoma protuberans. J Cancer Res Clin Oncol. 2009, 135: 653-665. 10.1007/s00432-009-0550-3CrossRefPubMed
31.
go back to reference Haycox CL, Odland PB, Olbricht SM, Casey B: Dermatofibrosarcoma protuberans (DFSP): growth characteristics based on tumor modeling and a review of cases treated with mohs micrographic surgery. Ann Plast Surg. 1997, 38: 246-251. 10.1097/00000637-199703000-00010CrossRefPubMed Haycox CL, Odland PB, Olbricht SM, Casey B: Dermatofibrosarcoma protuberans (DFSP): growth characteristics based on tumor modeling and a review of cases treated with mohs micrographic surgery. Ann Plast Surg. 1997, 38: 246-251. 10.1097/00000637-199703000-00010CrossRefPubMed
32.
go back to reference Weiss SW, Nickoloff BJ: CD-34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol. 1993, 17: 1039-1045. 10.1097/00000478-199310000-00009CrossRefPubMed Weiss SW, Nickoloff BJ: CD-34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol. 1993, 17: 1039-1045. 10.1097/00000478-199310000-00009CrossRefPubMed
33.
go back to reference Abenoza P, Lillemoe T: CD34 And factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. Am J Dermatopathol. 1993, 15: 429-434. 10.1097/00000372-199310000-00003CrossRefPubMed Abenoza P, Lillemoe T: CD34 And factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. Am J Dermatopathol. 1993, 15: 429-434. 10.1097/00000372-199310000-00003CrossRefPubMed
34.
go back to reference Zelger B, Sidoroff A, Stanzl U: Deep penetrating dermatofibroma versus dermatofibrosarcoma protuberans. A clinicopathologic comparison. Am J Surg Pathol. 1994, 18: 677-686. 10.1097/00000478-199407000-00003CrossRefPubMed Zelger B, Sidoroff A, Stanzl U: Deep penetrating dermatofibroma versus dermatofibrosarcoma protuberans. A clinicopathologic comparison. Am J Surg Pathol. 1994, 18: 677-686. 10.1097/00000478-199407000-00003CrossRefPubMed
35.
go back to reference Haycox CL, Odland PB, Olbricht SM, Piepkorn M: Immunohistochemical characterization of dermatofibrosarcoma protuberans with practical applications for diagnosis and treatment. J Am Acad Dermatol. 1997, 37: 438-444. 10.1016/S0190-9622(97)70146-4CrossRefPubMed Haycox CL, Odland PB, Olbricht SM, Piepkorn M: Immunohistochemical characterization of dermatofibrosarcoma protuberans with practical applications for diagnosis and treatment. J Am Acad Dermatol. 1997, 37: 438-444. 10.1016/S0190-9622(97)70146-4CrossRefPubMed
36.
go back to reference Naeem R, Lux ML, Huang SF, Naber SP, Corson JM, Fletcher JA: Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22. Am J Pathol. 1995, 147: 1553-1558.PubMedCentralPubMed Naeem R, Lux ML, Huang SF, Naber SP, Corson JM, Fletcher JA: Ring chromosomes in dermatofibrosarcoma protuberans are composed of interspersed sequences from chromosomes 17 and 22. Am J Pathol. 1995, 147: 1553-1558.PubMedCentralPubMed
37.
go back to reference O'Brien KP, Seroussi E, Dal Cin P: Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes Chromosomes Cancer. 1998, 23: 187-193. 10.1002/(SICI)1098-2264(199810)23:2<187::AID-GCC13>3.0.CO;2-LCrossRefPubMed O'Brien KP, Seroussi E, Dal Cin P: Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes Chromosomes Cancer. 1998, 23: 187-193. 10.1002/(SICI)1098-2264(199810)23:2<187::AID-GCC13>3.0.CO;2-LCrossRefPubMed
38.
go back to reference Nishio J, Iwasaki H, Ishiguro M: Supernumerary ring chromosome in a bednar tumor (pigmented dermatofibrosarcoma protuberans) is composed of interspersed sequences from chromosomes 17 and 22: a fluorescence in situ hybridization and comparative genomic hybridization analysis. Genes Chromosomes Cancer. 2001, 30: 305-309. 10.1002/1098-2264(2000)9999:9999<::AID-GCC1091>3.0.CO;2-RCrossRefPubMed Nishio J, Iwasaki H, Ishiguro M: Supernumerary ring chromosome in a bednar tumor (pigmented dermatofibrosarcoma protuberans) is composed of interspersed sequences from chromosomes 17 and 22: a fluorescence in situ hybridization and comparative genomic hybridization analysis. Genes Chromosomes Cancer. 2001, 30: 305-309. 10.1002/1098-2264(2000)9999:9999<::AID-GCC1091>3.0.CO;2-RCrossRefPubMed
39.
go back to reference Sirvent N, Maire G, Pedeutour F: Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer. 2003, 37: 1-19. 10.1002/gcc.10202CrossRefPubMed Sirvent N, Maire G, Pedeutour F: Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer. 2003, 37: 1-19. 10.1002/gcc.10202CrossRefPubMed
40.
go back to reference Takahira T, Oda Y, Tamiya S: Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans. Mod Pathol. 2007, 20: 668-675. 10.1038/modpathol.3800783CrossRefPubMed Takahira T, Oda Y, Tamiya S: Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans. Mod Pathol. 2007, 20: 668-675. 10.1038/modpathol.3800783CrossRefPubMed
41.
go back to reference Patel KU, Szabo SS, Hernandez VS: Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization assays. Hum Pathol. 2008, 39: 184-193. 10.1016/j.humpath.2007.06.009CrossRefPubMed Patel KU, Szabo SS, Hernandez VS: Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization assays. Hum Pathol. 2008, 39: 184-193. 10.1016/j.humpath.2007.06.009CrossRefPubMed
42.
go back to reference Simon MP, Pedeutour F, Sirvent N: Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet. 1997, 15: 95-98. 10.1038/ng0197-95CrossRefPubMed Simon MP, Pedeutour F, Sirvent N: Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet. 1997, 15: 95-98. 10.1038/ng0197-95CrossRefPubMed
43.
go back to reference Szollosi Z, Nemes Z: Transformed dermatofibrosarcoma protuberans: a clinicopathological study of eight cases. J Clin Pathol. 2005, 58: 751-756. 10.1136/jcp.2004.019349PubMedCentralCrossRefPubMed Szollosi Z, Nemes Z: Transformed dermatofibrosarcoma protuberans: a clinicopathological study of eight cases. J Clin Pathol. 2005, 58: 751-756. 10.1136/jcp.2004.019349PubMedCentralCrossRefPubMed
44.
go back to reference Roses DF, Valensi Q, LaTrenta G, Harris MN: Surgical treatment of dermatofibrosarcoma protuberans. Surg Gynecol Obstet. 1986, 162: 449-452.PubMed Roses DF, Valensi Q, LaTrenta G, Harris MN: Surgical treatment of dermatofibrosarcoma protuberans. Surg Gynecol Obstet. 1986, 162: 449-452.PubMed
45.
go back to reference Swan MC, Banwell PE, Hollowood K, Goodacre TE: Late recurrence of dermatofibrosarcoma protuberans in the female breast: a case report. Br J Plast Surg. 2005, 58: 84-87. 10.1016/j.bjps.2004.06.017CrossRefPubMed Swan MC, Banwell PE, Hollowood K, Goodacre TE: Late recurrence of dermatofibrosarcoma protuberans in the female breast: a case report. Br J Plast Surg. 2005, 58: 84-87. 10.1016/j.bjps.2004.06.017CrossRefPubMed
46.
go back to reference Sun LM, Wang CJ, Huang CC: Dermatofibrosarcoma protuberans: treatment results of 35 cases. Radiother Oncol. 2000, 57: 175-181. 10.1016/S0167-8140(00)00228-0CrossRefPubMed Sun LM, Wang CJ, Huang CC: Dermatofibrosarcoma protuberans: treatment results of 35 cases. Radiother Oncol. 2000, 57: 175-181. 10.1016/S0167-8140(00)00228-0CrossRefPubMed
47.
go back to reference Dagan R, Morris CG, Zlotecki RA, Scarborough MT, Mendenhall WM: Radiotherapy in the treatment of dermatofibrosarcoma protuberans. Am J Clin Oncol. 2005, 28: 537-539. 10.1097/01.coc.0000171278.69291.64CrossRefPubMed Dagan R, Morris CG, Zlotecki RA, Scarborough MT, Mendenhall WM: Radiotherapy in the treatment of dermatofibrosarcoma protuberans. Am J Clin Oncol. 2005, 28: 537-539. 10.1097/01.coc.0000171278.69291.64CrossRefPubMed
48.
go back to reference Lindner NJ, Scarborough MT, Powell GJ, Spanier S, Enneking WF: Revision surgery in dermatofibrosarcoma protuberans of the trunk and extremities. Eur J Surg Oncol. 1999, 25: 392-397. 10.1053/ejso.1999.0663CrossRefPubMed Lindner NJ, Scarborough MT, Powell GJ, Spanier S, Enneking WF: Revision surgery in dermatofibrosarcoma protuberans of the trunk and extremities. Eur J Surg Oncol. 1999, 25: 392-397. 10.1053/ejso.1999.0663CrossRefPubMed
49.
go back to reference Maki RG, D'Adamo DR, Keohan ML: Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol. 2009, 27: 3133-3140. 10.1200/JCO.2008.20.4495PubMedCentralCrossRefPubMed Maki RG, D'Adamo DR, Keohan ML: Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol. 2009, 27: 3133-3140. 10.1200/JCO.2008.20.4495PubMedCentralCrossRefPubMed
50.
go back to reference Jhanwar SC, Chen Q, Li FP, Brennan MF, Woodruff JM: Cytogenetic analysis of soft tissue sarcomas. Recurrent chromosome abnormalities in malignant peripheral nerve sheath tumors (MPNST). Cancer Genet Cytogenet. 1994, 78: 138-144. 10.1016/0165-4608(94)90081-7CrossRefPubMed Jhanwar SC, Chen Q, Li FP, Brennan MF, Woodruff JM: Cytogenetic analysis of soft tissue sarcomas. Recurrent chromosome abnormalities in malignant peripheral nerve sheath tumors (MPNST). Cancer Genet Cytogenet. 1994, 78: 138-144. 10.1016/0165-4608(94)90081-7CrossRefPubMed
51.
go back to reference Johnson MR, DeClue JE, Felzmann S: Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function. Mol Cell Biol. 1994, 14: 641-645.PubMedCentralCrossRefPubMed Johnson MR, DeClue JE, Felzmann S: Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function. Mol Cell Biol. 1994, 14: 641-645.PubMedCentralCrossRefPubMed
52.
go back to reference Mori S, Satoh T, Koide H, Nakafuku M, Villafranca E, Kaziro Y: Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems. J Biol Chem. 1995, 270: 28834-28838. 10.1074/jbc.270.48.28834CrossRefPubMed Mori S, Satoh T, Koide H, Nakafuku M, Villafranca E, Kaziro Y: Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems. J Biol Chem. 1995, 270: 28834-28838. 10.1074/jbc.270.48.28834CrossRefPubMed
Metadata
Title
Dermatofibrosarcoma protuberans (DFSP) successfully treated with sorafenib: case report
Authors
Francois G Kamar
Victor F Kairouz
Alain N Sabri
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Clinical Sarcoma Research / Issue 1/2013
Electronic ISSN: 2045-3329
DOI
https://doi.org/10.1186/2045-3329-3-5

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