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Open Access 01-12-2014 | Case report

Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall

Authors: Massimo Colaneri, Andrea Quarti, Marco Pozzi, Stefano Gasparini, Ines Carloni, Fernando Maria de Benedictis

Published in: Italian Journal of Pediatrics | Issue 1/2014

Abstract

Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for this devastating disease is advocated.

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Title: Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall
Authors: Massimo Colaneri
Andrea Quarti
Marco Pozzi
Stefano Gasparini
Ines Carloni
Fernando Maria de Benedictis
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2014
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/1824-7288-40-18

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Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall

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