Published in:
Open Access
01-12-2010 | Poster presentation
A case of nodular regenerative hyperplasia in a patient who had been taking didanosine
Authors:
C Jackson, R Fox, M Priest, D Clutterbuck, E Peters
Published in:
Journal of the International AIDS Society
|
Special Issue 4/2010
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Excerpt
It is widely recognised that liver disease causes significant morbidity and mortality in HIV positive patients. Many patients are co-infected with hepatitis B and C, have increased alcohol intake or are on hepatotoxic medication e.g. nevirapine, which can cause acute hepatitis or liver cirrhosis. Nodular regenerative hyperplasia (NRH) is characterised by the presence of diffuse, small regenerative nodules in the absence of significant cirrhosis. Prior use of didanosine is associated with NRH. It leads to portal hypertension, oesophageal varices and subsequent gastrointestinal haemorrhage. …