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Gut Pathogens
Published in: Gut Pathogens 1/2013

Open Access 01-12-2013 | Research

Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii

Authors: Indu Khatri, Akil Akhtar, Kamaldeep Kaur, Rajul Tomar, Gandham Satyanarayana Prasad, Thirumalai Nallan Chakravarthy Ramya, Srikrishna Subramanian

Published in: Gut Pathogens | Issue 1/2013

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Abstract

Background

The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently available in the public domain.

Results

We report the 11.4 Mbp draft genome of this probiotic yeast. The draft genome was obtained by assembling Roche 454 FLX + shotgun data into 194 contigs with an N50 of 251 Kbp. We compare our draft genome with all other Saccharomyces cerevisiae genomes.

Conclusions

Our analysis confirms the close similarity of S. boulardii to S. cerevisiae strains and provides a framework to understand the probiotic effects of this yeast, which exhibits unique physiological and metabolic properties.
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Metadata
Title
Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii
Authors
Indu Khatri
Akil Akhtar
Kamaldeep Kaur
Rajul Tomar
Gandham Satyanarayana Prasad
Thirumalai Nallan Chakravarthy Ramya
Srikrishna Subramanian
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Gut Pathogens / Issue 1/2013
Electronic ISSN: 1757-4749
DOI
https://doi.org/10.1186/1757-4749-5-30

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