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Open Access 01-12-2012 | Case report

Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature

Authors: Masaaki Takai, Masanori Kanemura, Hiroshi Kawaguchi, Satoe Fujiwara, Saha Yoo, Yoshimichi Tanaka, Satoshi Tsunetoh, Yoshito Terai, Takashi Yamada, Masahide Ohmichi

Published in: Journal of Ovarian Research | Issue 1/2012

Abstract

Background

Mature cystic teratomas (MCTs) are the most common germ cell tumors of the ovary. Malignant tranformation occurs in 1-2% of these neoplasms. Although most of the malignancies arising from MCTs are squamous cell carcinomas, adenocarcinoma of the gastrointestinal type is extremery rare. We herein present a case of adenocarcinoma of the intestinal type arising from a MCT.

Case

A 49-year-old female underwent surgery for a left ovarian tumor. The histology of the cyst walls revealed a MCT with a few hair shafts and a squamous layer, while another part of the tumor showed adenocarcinoma of the intestinal type. Five years after surgery, she is alive without disease.

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Peterson WF: Malignant degeneration of benign cystic teratomas of the overy; a collective review of the literature. Obstet Gynecol Surv 1957, 12: 793–830. 10.1097/00006254-195712000-00001PubMedCrossRef

Ueda G, Fujita M, Ogawa H, Sawada M, Inoue M, Tanizawa O: Adenocarcinoma in a benign cystic teratoma of the ovary: report of a case with a long survival period. Gynecol Oncol 1993, 48: 259–263. 10.1006/gyno.1993.1044PubMedCrossRef

Min KJ, Jee BC, Lee HS, Kim YB: Intestinal adenocarcinoma arising in a mature cystic teratoma of the ovary: a case report. Pathol Res Pract 2006, 202: 531–535. 10.1016/j.prp.2006.03.005PubMedCrossRef

Fishman A, Edelstein E, Altaras M, Beyth Y, Bernheim J: Adenocarcinoma arising from the gastrointestinal epithelium in benign cystic teratoma of the ovary. Gynecol Oncol 1998, 70: 418–420. 10.1006/gyno.1998.5123PubMedCrossRef

Levine DA, Villella JA, Poynor EA, Soslow RA: Gastrointestinal adenocarcinoma arising in a mature cystic teratoma of the ovary. Gynecol Oncol 2004, 94: 597–599. 10.1016/j.ygyno.2004.05.045PubMedCrossRef

Kushima M: Adenocarcinoma arising from mature cystic teratoma of the ovary. Pathol Int 2004, 54: 139–143. 10.1111/j.1440-1827.2004.01599.xPubMedCrossRef

Guney M, Oral B, Demir F, Ozsoy M, Kapucuoglu N: Mucinous adenocarcinoma arising from the gastrointestinal epithelium in benign cystic teratoma of the ovary–case report. Eur J Gynaecol Oncol 2006, 27: 304–306.PubMed

Koonings PP, Campbell K, Mishell DR, Grimes DA: Relative frequency of primary ovarian neoplasms: a 10-year review. Obstet Gynecol 1989, 74: 921–926.PubMed

Hackethal A, Brueggmann D, Bohlmann MK, Franke FE, Tinneberg HR, Münstedt K: Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data. Lancet Oncol. 2008, 9: 1173–1180. 10.1016/S1470-2045(08)70306-1PubMedCrossRef

10.

Suzuki M, Tamura N, Kobayashi H, Ohwada M, Terao T, Sato I: Clinical significance of combined use of macrophage colony-stimulating factor and squamous cell carcinoma antigen as a selective diagnostic marker for squamous cell carcinoma arising in mature cystic teratoma of the ovary. Gynecol Oncol 2000, 77: 405–409. 10.1006/gyno.2000.5784PubMedCrossRef

11.

Kikkawa F, Nawa A, Tamakoshi K, Ishikawa H, Kuzuya K, Suganuma N, Hattori S, Furui K, Kawai M, Arii Y: Diagnosis of squamous cell carcinoma arising from mature cystic teratoma of the ovary. Cancer 1998, 82: 2249–2255. 10.1002/(SICI)1097-0142(19980601)82:11<2249::AID-CNCR21>3.0.CO;2-TPubMedCrossRef

12.

Miyazaki K, Tokunaga T, Katabuchi H, Ohba T, Tashiro H, Okamura H: Clinical usefulness of serum squamous cell carcinoma antigen for early detection of squamous cell carcinoma arising in mature cystic teratoma of the ovary. Obstet Gynecol 1991, 78: 562–566.PubMed

13.

Rim SY, Kim SM, Choi HS: Malignant transformation of ovarian mature cystic teratoma. Int J Gynecol Cancer. 2006, 16: 140–144. 10.1111/j.1525-1438.2006.00285.xPubMedCrossRef

14.

Bal A, Mohan H, Singh SB, Sehgal A: Malignant transformation in mature cystic teratoma of the ovary: report of five cases and review of the literature. Arch Gynecol Obstet 2007, 275: 179–182. 10.1007/s00404-006-0244-xPubMedCrossRef

15.

Kido A, Togashi K, Konishi I, Kataoka ML, Koyama T, Ueda H, Fujii S, Konishi J: Dermoid cysts of the ovary with malignant transformation: MR appearance. AJR Am J Roentgenol 1999, 172: 445–449.PubMedCrossRef

16.

Takemori M, Nishimura R: MRI findings of an ovarian dermoid cyst with malignant transformation. Magn Reson Med Sci. 2003, 2: 105–108. 10.2463/mrms.2.105PubMedCrossRef

17.

Park SB, Kim JK, Kim KR, Cho KS: Preoperative diagnosis of mature cystic teratoma with malignant transformation: analysis of imaging findings and clinical and laboratory data. Arch Gynecol Obstet 2007, 275: 25–31.PubMedCrossRef

18.

Yahata T, Kawasaki T, Serikawa T, Suzuki M, Tanaka K: Adenocarcinoma arising from respiratory ciliated epithelium in benign cystic teratoma of the ovary: a case report with analyzes of the CT, MRI, and pathological findings. J Obstet Gynaecol Res 2008, 34: 408–412. 10.1111/j.1447-0756.2008.00784.xPubMedCrossRef

Title: Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature
Authors: Masaaki Takai
Masanori Kanemura
Hiroshi Kawaguchi
Satoe Fujiwara
Saha Yoo
Yoshimichi Tanaka
Satoshi Tsunetoh
Yoshito Terai
Takashi Yamada
Masahide Ohmichi
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Ovarian Research / Issue 1/2012
Electronic ISSN: 1757-2215
DOI: https://doi.org/10.1186/1757-2215-5-41

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Mucinous adenocarcinoma of the intestinal type arising from mature cystic teratoma of the ovary: a rare case report and review of the literature

Abstract

Background

Case

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Case

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