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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2013

Open Access 01-12-2013 | Case report

Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke–Löwenstein tumor): a case report and review of the literature

Authors: Mustapha Ahsaini, Yasser Tahiri, Mohammed Fadl Tazi, Jallaledine Elammari, Soufiane Mellas, Abdelhak Khallouk, Mohammed Jamal El Fassi, My Hassan Farih, Hind Elfatmi, Afaf Amarti, Roos E Stuurman-Wieringa

Published in: Journal of Medical Case Reports | Issue 1/2013

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Abstract

Introduction

Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential.

Case presentation

We report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke–Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later.

Conclusions

The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke–Löwenstein tumor) and discuss the literature on its diagnosis and management.
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Literature
1.
Ackerman LV: Verrucous carcinoma of the oral cavity. Surgery. 1948, 23: 670-678.PubMed
2.
Trombetta LJ, Place RJ: Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature. Dis Colon Rectum. 2001, 44: 1878-1886. 10.1007/BF02234473.CrossRefPubMed
3.
Dogan G, Oram Y, Hazneci E, Ozen S, Karincaoglu Y, Ciralik H: Three cases of verrucous carcinoma. Australas J Dermatol. 1998, 39: 251-254. 10.1111/j.1440-0960.1998.tb01484.x.CrossRefPubMed
4.
Buschke A, Löwenstein L: Über carcinomähnliche condylomata accuminata des Penis. Klin Wochenschr. 1925, 4: 1726-1728. 10.1007/BF01728480.CrossRef
5.
Masih AS, Stoler MH, Farrow GM, Wooldridge TN, Johansson SL: Penile verrucous carcinoma: a clinicopathologic, human papillomavirus typing and flow cytometric analysis. Mod Pathol. 1992, 5: 48-55.PubMed
6.
Pilotti S, Donghi R, D’Amato L: HPV detection and p53 alteration in squamous cell verrucous malignancies of the lower genital tract. Diagn Mol Pathol. 1993, 2: 248-256.CrossRefPubMed
7.
Cupp MR, Malek RS, Goellner JR, Smith TF, Espy MJ: The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis. J Urol. 1995, 154: 1024-1029. 10.1016/S0022-5347(01)66967-2.CrossRefPubMed
8.
Dianzani C, Bucci M, Pierangeli A, Calvieri S, Degener M: Association of human papilloma virus type 11 with carcinoma of the penis. Urology. 1998, 51: 1046-1048. 10.1016/S0090-4295(98)00105-8.CrossRefPubMed
9.
Gillard P, Vanhooteghem O, Richert B, De La Brasine M: Tumor de Buschke-Loewenstein. Ann Dermatol Venereol. 2005, 132: 98-99.CrossRefPubMed
10.
Majewski S, Jablonska S: Human papillomavirus-associated tumors of the skin and mucosa. J Am Acad Dermatol. 1997, 36 (5 Pt 1): 659-685.CrossRefPubMed
11.
Geusau A, Heinz-Peer G, Volc-Platzer B, Stingl G, Kirnbauer R: Regression of deeply infiltrating giant condyloma (Buschke-Löwenstein tumor) following long-term intralesional interferon alfa therapy. Arch Dermatol. 2000, 136: 707-710.CrossRefPubMedPubMedCentral
12.
Chu QD, Vereridis MP, Libbey NP, Wanebo HJ: Giant condyloma acuminatum (Buschke Lowenstein tumor) of the anorectal and perianal regions. Dis Colon Rectum. 1994, 37: 950-957. 10.1007/BF02052606.CrossRefPubMed
13.
Creasman C, Haas PA, Fox TA, Balazs M: Malignant transformation of anorectal giant condyloma acuminatum (Buschke Lowenstein tumor). Dis Colon Rectum. 1989, 32: 481-487. 10.1007/BF02554502.CrossRefPubMed
14.
Bertram P, Treutner KH, Rubben A, Hauptmann S, Schumpelick V: Invasive squamous cell carcinoma in giant anorectal condyloma (Buschke Lowenstein tumor). Langenbecks Arch Chir. 1995, 380: 115-118.CrossRefPubMed
15.
El Mejjad A, Amine El M, Mohamed D, Mohamed T, Hichame A, Abdeltif C, Ahmed A, Rachid A, Fethi M: Le condylome acuminé géant-tumeur de Buschke Loewenstein (à propos de 3 cas). Prog Urol. 2003, 13 (3): 513-517.PubMed
16.
Blake PA, Kim CO, Lopez AE, Krongrad A: Verrucous carcinoma of a suprapubic cystostomy track. J Urol. 1996, 156: 174-10.1016/S0022-5347(01)65981-0.CrossRefPubMed
17.
Levy A, Lebbe C: Buschke-Lowenstein tumor: diagnosis and treatment. Ann Urol (Paris). 2006, 40: 175-178. 10.1016/j.anuro.2006.02.002.CrossRef
18.
Chao MW, Gibbs P: Squamous cell carcinoma arising in a giant condyloma acuminatum (Buschke-Lowenstein tumor). Asian J Surg. 2005, 28: 238-240. 10.1016/S1015-9584(09)60352-3.CrossRefPubMed
19.
Merzouk M, Moumen M, Biadillah MCH: Tumeur de Buschke Löwenstein de localisation ano-perianale dégénérée: a propose de 2 cas. Médecine du Maghreb. 1992, 35: 21-22.
20.
Sheen MC, Sheu HM, Chai CY, Huang CH, Chuang JH, Lin TM, Wang YW: Clinical and histological effects of aortic infusion of methotrexate for penile squamous cell carcinoma. Reg Cancer Treat. 1994, 7: 27-32.
21.
Qarro A, Ait Ali A, Choho A, Alkandry S, Borki K: Tumeur de Buschke Loewenstein à localisation anorectale (à propos de trois cas). Ann Chir. 2005, 130: 96-100. 10.1016/j.anchir.2004.06.005.CrossRefPubMed
22.
Fukunaga M, Yokoi K, Miyazawa Y, Harada T, Ushigome S: Penile verrucous carcinoma anaplastic transformation following radiotherapy: a case report with human papillomavirus typing and flow cytometric DNA studies. Am J Surg Pathol. 1994, 18: 501-10.1097/00000478-199405000-00010.CrossRefPubMed
23.
Munro A: UKCCCR Anal cancer ACT II Trial. BJC. 2000, 83 Suppl 1 (S17): 7-
24.
Elliot MS, Werner ID, Immelman EJ, Harrison AC: Giant condyloma of the anorectum. Dis Colon Rectum. 1979, 22: 497-500. 10.1007/BF02586940.CrossRefPubMed
25.
Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, Gilbert J: Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour. Surgeon. 2006, 4: 378-383. 10.1016/S1479-666X(06)80114-9.CrossRefPubMed
26.
Wiltz OH, Torregrosa M, Wiltz O: Autogenous vaccine: the best therapy for perianal condyloma acuminata?. Dis Colon Rectum. 1995, 38: 838-841. 10.1007/BF02049840.CrossRefPubMed
Metadata
Title
Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke–Löwenstein tumor): a case report and review of the literature
Authors
Mustapha Ahsaini
Yasser Tahiri
Mohammed Fadl Tazi
Jallaledine Elammari
Soufiane Mellas
Abdelhak Khallouk
Mohammed Jamal El Fassi
My Hassan Farih
Hind Elfatmi
Afaf Amarti
Roos E Stuurman-Wieringa
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2013
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-7-273

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