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Journal of Medical Case Reports

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Open Access 01-12-2013 | Case report

Treatment strategy for reducing the risk of rituximab-induced cytokine release syndrome in patients with intravascular large B-cell lymphoma: a case report and review of the literature

Authors: Katsuhiro Makino, Jumi Nakata, Satoru Kawachi, Tatsuyuki Hayashi, Atsuo Nakajima, Munehiro Yokoyama

Published in: Journal of Medical Case Reports | Issue 1/2013

Abstract

Introduction

Intravascular large B-cell lymphoma is a rare aggressive disseminated disease characterized by the presence of lymphoma cells in small vessels without lymphadenopathy. Rituximab, a novel monoclonal antibody against the CD20 B-cell antigen, has been reported to be effective in treating intravascular large B-cell lymphoma. However, adverse events have been reported in association with rituximab infusion.

Case presentation

We report the case of a 54-year-old Japanese man diagnosed with Asian variant intravascular large B-cell lymphoma who died within five hours of the initiation of a first course of chemotherapy including rituximab. Autopsy results suggested that the patient died of severe systemic inflammatory response syndrome. A literature review revealed that rituximab administered during the second course of chemotherapy (instead of during the first course) appears to reduce the incidence of infusion reactions (from 48% to 15%) without altering the frequency of complete remission outcomes.

Conclusions

Our data indicate that the incidence of adverse reactions to rituximab can be markedly decreased if the tumor load is first reduced with an initial course of chemotherapy excluding rituximab. Future prospective studies of the timing of rituximab administration are warranted.

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Title: Treatment strategy for reducing the risk of rituximab-induced cytokine release syndrome in patients with intravascular large B-cell lymphoma: a case report and review of the literature
Authors: Katsuhiro Makino
Jumi Nakata
Satoru Kawachi
Tatsuyuki Hayashi
Atsuo Nakajima
Munehiro Yokoyama
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2013
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-7-280

At a glance: The STEP trials

Springer Medicine

Treatment strategy for reducing the risk of rituximab-induced cytokine release syndrome in patients with intravascular large B-cell lymphoma: a case report and review of the literature

Abstract

Introduction

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusions

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