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Journal of Medical Case Reports
Published in: Journal of Medical Case Reports 1/2010

Open Access 01-12-2010 | Case report

Squamous cell carcinoma of rectum presenting in a man: a case report

Authors: A Syed Sameer, Nidda Syeed, Nissar A Chowdri, Fazl Q Parray, Mushtaq A Siddiqi

Published in: Journal of Medical Case Reports | Issue 1/2010

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Abstract

Background

Primary squamous cell carcinomas of the colorectum are very uncommon. Until now, to the best of our knowledge, only 114 cases of squamous cell carcinoma in the colorectum exist in the reported literature. Here we report a case of squamous cell carcinoma of the rectum in the ethnic Kashmiri population in northern India.

Case Presentation

The case of a 60-year-old male patient (Asian) with a pure squamous cell carcinoma of the rectum is presented here. The patient underwent a curative surgery with concomitant chemotherapy. Two years after the initial curative resection of the tumor he is still alive.

Conclusion

The prognosis for squamous cell carcinoma of the colorectum is worse than for that of adenocarcinoma, because of the delayed diagnosis. The etiopathogenicity of squamous cell carcinoma of the colorectum is discussed. Surgical resection of the lesion seems to be the treatment of choice. Chemotherapy also helps in improvement of the prognosis.
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Literature
1.
Miyamotoa H, Nishiokaa M, Kuritaa N, Hondaa J, Yoshikawaa K, Higashijimaa J, Miyatania T, Bandoub Y, Shimadaa M: Squamous cell carcinoma of the descending colon: report of a case and literature review. Case Rep Gastroenterol. 2007, 1: 77-83. 10.1159/000107470.CrossRef
2.
Gelas T, Peyrat P, Francois Y, Gerard JP, Baulieux J, Gilly FN, Vignal J, Glehen O: Primary squamous-cell carcinoma of the rectum: report of six cases and review of the literature. Dis Colon Rectum. 2002, 45: 1535-1540. 10.1007/s10350-004-6462-z.CrossRefPubMed
3.
Sameer AS, Rehman S, Pandith AA, Syeed N, Shah ZA, Chowdhri NA, Wani KA, Siddiqi MA: Molecular gate keepers succumb to gene aberrations in colorectal cancer in Kashmiri population, revealing a high incidence area. Saudi J Gastroenterol. 2009, 15: 244-252. 10.4103/1319-3767.56102.CrossRefPubMedPubMedCentral
4.
5.
Nahas CS, Shia J, Joseph R, Schrag D, Minsky BD, Weiser MR, Guillem JG, Paty PB, Klimstra DS, Tang LH, Wong WD, Temple LK: Squamous-cell carcinoma of the rectum: a rare but curable tumor. Dis Colon Rectum. 2007, 50: 1393-1400. 10.1007/s10350-007-0256-z.CrossRefPubMed
6.
Schmidtmann M: Zur Kenntnis seltener Krebsformen. Virchow Arch (A). 1919, 226: 100-118. 10.1007/BF02039541.CrossRef
7.
Anagnostopoulos G, Sakorafas GH, Kostopoulos P, Grigoriadis K, Pavlakis G, Margantinis G, Vugiouklakis D, Arvanitidis D: Squamous cell carcinoma of the rectum: a case report and review of the literature. Eur J Cancer Care Engl. 2005, 14: 70-74. 10.1111/j.1365-2354.2005.00523.x.CrossRefPubMed
8.
Raiford TS: Epitheliomata of the lower rectum and anus. Surg Gynecol Obstet. 1933, 57: 21-35.
9.
Bhat S, Pai M, Premnath RP: Primary squamous cell carcinoma of caecum. Indian J Cancer. 2003, 40: 118-119.PubMed
10.
Mel'nikov RA, Goshchitskiĭ LG, Kovalev VK: Clinical manifestations of squamous cell carcinoma of the rectum. Vopr Onkol. 1984, 30: 76-83.PubMed
11.
Williams GT, Blackshaw AJ, Morson BC: Squamous carcinoma of the colorectum and its genesis. J Pathol. 1979, 129: 139-147. 10.1002/path.1711290306.CrossRefPubMed
12.
Carroll D, Rajesh PB: Colonic metastases from primary squamous cell carcinoma of the lung. Eur J Cardiothorac Surg. 2001, 19: 719-720. 10.1016/S1010-7940(01)00646-7.CrossRefPubMed
13.
Lafreniere R, Ketcham AS: Primary squamous carcinoma of the rectum. Report of a case and review of the literature. Dis Colon Rectum. 1985, 28: 967-972. 10.1007/BF02554319.CrossRefPubMed
14.
Comer TP, Beahrs OH, Dockerty MB: Primary squamous cell carcinoma and adenoacanthoma of the colon. Cancer. 1971, 58: 111-117.
15.
Michelassi F, Montag AG, Block GE: Adenosquamous-cell carcinoma in ulcerative colitis. Report of a case. Dis Colon Rectum. 1988, 31: 323-326.
16.
Ouban A, Nawab RA, Coppola D: Diagnostic and pathogenetic implications of colorectal carcinomas with multidirectional differentiation: a report of 4 cases. Clin Colorectal Cancer. 2002, 1: 243-248. 10.3816/CCC.2002.n.006.CrossRefPubMed
17.
Fu K, Tsujinaka Y, Hamahata Y, Matsuo K, Tsutsumi O: Squamous metaplasia of the rectum associated with ulcerative colitis diagnosed using narrow-band imaging. Endoscopy. 2008, 40: E45-E46. 10.1055/s-2007-966861.CrossRefPubMed
18.
Audeau A, Han HW, Johnston MJ, Whitehead MW, Frizelle FA: Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum?. Eur J Surg Oncol. 2002, 28: 657-660. 10.1053/ejso.2002.1304.CrossRefPubMed
19.
Yurdakul G, de Reijke TM, Blank LE, Rauws EA: Rectal squamous cell carcinoma 11 years after brachytherapy for carcinoma of the prostate. J Urol. 2003, 169: 280-10.1016/S0022-5347(05)64092-X.CrossRefPubMed
20.
Jaworski RC, Biankin SA, Baird PJ: Squamous cell carcinoma in situ arising in inflammatory cloacogenic polyps: report of two cases with PCR analysis for HPV DNA. Pathology. 2001, 33: 312-314. 10.1080/00313020120062901.CrossRefPubMed
21.
Theodosopoulos TK, Marinis AD, Dafnios NA, Vassiliou JG, Samanides LD, Carvounis EE, Smyrniotis VE: Aggressive treatment of metastatic squamous cell carcinoma of the rectum to the liver: a case report and a brief review of the literature. World Journal of Surgical Oncology. 2006, 4: 49-10.1186/1477-7819-4-49.CrossRefPubMedPubMedCentral
22.
Catell RB, Williams AG: Epidermoid carcinoma of the anus and rectum. Arch Surg. 1943, 46: 336-349.CrossRef
23.
Wiener MF, Polayes SH, Yidi R: Squamous carcinoma with schistosomiasis of the colon. Am J Gastroent. 1962, 37: 48-54.PubMed
24.
Larizaden R, Powell DE: Neoplastic change in a duplicated colon. Br J Surg. 1965, 52: 666-668. 10.1002/bjs.1800520907.CrossRef
25.
Cabrera A, Pickren JW: Squamous metaplasia and squamous-cell carcinoma of the rectosigmoid. Dis Colon Rectum. 1967, 10: 288-297. 10.1007/BF02617142.CrossRefPubMed
26.
Minkowitz S: Primary squamous cell carcinoma of the rectosigmoid portion of the colon. Arch Pathol. 1967, 84: 77-80.PubMed
27.
Gaston EA: Squamous-cell carcinoma of the colon and rectum: report of a case. Dis Colon Rectum. 1967, 10: 435-434. 10.1002/path.1711290306.CrossRefPubMed
28.
Pemberton M, Lendrum J: Squamous-cell carcinoma of the caecum following ovarian adenocarcinoma. Br J Surg. 1968, 55: 273-276. 10.1002/bjs.1800550409.CrossRefPubMed
29.
Birnbaum W: Squamous cell carcinoma and adenoacanthoma of the colon. JAMA. 1970, 212: 1511-1513. 10.1001/jama.212.9.1511.CrossRefPubMed
30.
Lewis PL, Harrer WV, Sencindiver PV: Primary squamous-cell carcinoma of the cecum: report of a case. Dis Colon Rectum. 1971, 14: 213-217. 10.1007/BF02553188.CrossRefPubMed
31.
Balfour TW: Does squamous carcinoma of the colon exist?. Br J Surg. 1972, 59: 410-412. 10.1002/bjs.1800590523.CrossRefPubMed
32.
Horne BD, McCulloch CF: Squamous cell carcinoma of the cecum: a case report. Cancer. 1978, 42: 1879-1882. 10.1002/1097-0142(197810)42:4<1879::AID-CNCR2820420427>3.0.CO;2-4.CrossRefPubMed
33.
Crissman JD: Adenosquamous and squamous cell carcinoma of the colon. Am J Surg Pathol. 1978, 2: 47-54. 10.1097/00000478-197803000-00006.CrossRefPubMed
34.
Burgess PA, Lupton EW, Talbot IC: Squamous-cell carcinoma of the proximal colon: report of a case and review of the literature. Dis Colon Rectum. 1979, 22: 241244-CrossRef
35.
Lasser P, Elias D, Eschwege F: A propos de 3 cas d'epitheliomas epidermoides du rectum. J Chir. 1980, 117: 377-380.
36.
Hickey WF, Corson JM: Squamous cell carcinoma arising in a duplication of the colon: case report and literature review of squamous cell carcinoma of the colon and of malignancy complicating colonic duplication. Cancer. 1981, 47: 602-609. 10.1002/1097-0142(19810201)47:3<602::AID-CNCR2820470330>3.0.CO;2-8.CrossRefPubMed
37.
Petrelli M, Tetangco E, Reid JD: Carcinoma of the colon with undifferentiated, carcinoid, and squamous cell features. Am J Clin Pathol. 1981, 75: 581-584.CrossRefPubMed
38.
Pittella JE, Torres AV: : Primary squamous-cell carcinoma of the cecum and ascending colon: report of a case and review of the literature. Dis Colon Rectum. 1982, 25: 483-487. 10.1007/BF02553663.CrossRefPubMed
39.
Hey A, Brandt G: [A pure squamous cell carcinoma of the large intestine. Report of 3 personal observations and a literature review]. Pathologe. 1982, 3: 359-364.PubMed
40.
Lyttle JA: Primary squamous carcinoma of the proximal large bowel. Report of a case and review of the literature. Dis Colon Rectum. 1983, 26: 279-282. 10.1007/BF02562498.CrossRefPubMed
41.
Vezeridis MP, Herrera LO, Lopez GE, Ledesma EJ, Mittleman A: Squamous-cell carcinoma of the colon and rectum. Dis Colon Rectum. 1983, 26: 188-191. 10.1007/BF02560169.CrossRefPubMed
42.
Gould L, Shah JM, Khedekar RR, Burns WA: Squamous cell carcinoma of the splenic flexure of the colon. Dig Dis Sci. 1983, 28: 918-922. 10.1007/BF01317044.CrossRefPubMed
43.
Francioni G, Canuti S, Cardelli A, Montesi M: [Epidermoid carcinoma of the colon. Clinical case of double recto-sigmoid basalioma]. Minerva Dietol Gastroenterol. 1983, 29: 33-38.PubMed
44.
Forouhar F: Neoplastic colonic polyp with extensive squamous metaplasia. Case report. Tumori. 1984, 70: 99-103.PubMed
45.
46.
Chulia F, Camps C, Rodriguez A, Medina E, Tuset J: Epidermoid carcinoma of the colon. Description of a lesion located in the hepatic flexure. Dis Colon Rectum. 1986, 29: 665-667. 10.1007/BF02560334.CrossRefPubMed
47.
Weidner N, Zekan P: Carcinosarcoma of the colon - Report of a unique case with light and immuoistochemical studies. Cancer. 1986, 58: 1126-1130. 10.1002/1097-0142(19860901)58:5<1126::AID-CNCR2820580525>3.0.CO;2-Q.CrossRefPubMed
48.
Piggott JP, Williams GB: Primary squamous cell carcinoma of the colorectum: case report and literature review of a rare entity. J Surg Oncol. 1987, 35: 117-119. 10.1002/jso.2930350211.CrossRef
49.
Woods WG: Squamous cell carcinoma of the rectum arising in an area of squamous metaplasia. Eur J Surg Oncol. 1987, 13: 455-458.PubMed
50.
Shao YF, Pan GL, Zhou CN, Yu HT: : [Squamous cell carcinoma of the ascending colon--a case report and review of literature]. Zhonghua Zhong Liu Za Zhi. 1987, 9: 315-316.PubMed
51.
Prener A, Nielsen K: Primary squamous cell carcinoma of the rectum in Denmark. APMIS. 1988, 96: 839-844. 10.1111/j.1699-0463.1988.tb00951.x.CrossRefPubMed
52.
Lundquest DE, Marcus JN, Thorson AG, Massop D: : Primary squamous cell carcinoma of the colon arising in a villous adenoma. Hum Pathol. 1988, 19: 362-364. 10.1016/S0046-8177(88)80532-X.CrossRefPubMed
53.
Wyatt MG, Clarke TJ, Teasdale C: Primary squamous cell carcinoma of the caecum. Eur J Surg Oncol. 1991, 17: 392-394.PubMed
54.
Schneider TA, Birkett DH, Vernava AM: Primary adenosquamous and squamous cell carcinoma of the colon and rectum. Int J Colorectal Dis. 1992, 7: 144-147. 10.1007/BF00360355.CrossRefPubMed
55.
Betancourt C, Berríos G, Peña E: : [Squamous cell carcinoma of the colon. A case report]. G E N. 1992, 46: 331-335.PubMed
56.
Vignale R, Espasandin J, Deneo H, Gonzalez V: : Halo seborrheic keratosis associated with colon carcinoma. Int J Dermatol. 1993, 32: 846-10.1111/j.1365-4362.1993.tb02784.x.CrossRefPubMed
57.
Yoshida J, Tohma H, Nagata T, Okuzono Y, Takahashi M: Squamous cell carcinoma of the splenic flexure of the colon: report of a case. Surg Today. 1994, 24: 75-79. 10.1007/BF01676891.CrossRefPubMed
58.
Vraux H, Kartheuser A, Haot J, Humblet Y, Detry R, Dive C, Kestens PJ: Primary squamous-cell carcinoma of the colon: a case report. Acta Chir Belg. 1994, 94: 318-320.PubMed
59.
Alekseev VS, Boĭkov VP, Pavlov NV, Karyshev PB: [Squamous cell cancer of the colon with inflammation]. 1994, Khirurgiia Mosk, 12: 58-
60.
Petrelli NJ, Valle AA, Weber TK, Rodriguez-Bigas M: Adenosquamous adenocarcinoma of the colon and rectum. Dis Colon Rectum. 1996, 39: 1265-1268. 10.1007/BF02055120.CrossRefPubMed
61.
Martinez-Gonzalez MD, Takahashi T, Leon-Rodriguez E, Gamboa-Dominguez A, Lome C, Garcia-Blanco MC, Bezaury P, Moran MA: Case report of primary squamous carcinoma of the rectum. Rev Invest Clin. 1996, 48: 453-456.PubMed
62.
Juturi JV, Francis B, Koontz PW, Wilkes JD: Squamous-cell carcinoma of the colon responsive to combination chemotherapy: report of two cases and review of the literature. Dis Colon Rectum. 1999, 42: 102-109. 10.1007/BF02235191.CrossRefPubMed
63.
Kim JH, Moon WS, Kang MJ, Park MJ, Lee DG: Sarcomatoid carcinoma of the colon: a case report. J Korean. Med Sci. 2001, 16: 657-660.
64.
Copur S, Ledakis P, Novinski D, Mleczko KL, Frankforter S, Bolton M, Fruehling RM, VanWie E, Norvell M, Muhvic J: Squamous cell carcinoma of the colon with an elevated serum squamous cell carcinoma antigen responding to combination chemotherapy. Clin Colorectal Cancer. 2001, 1: 55-58. 10.3816/CCC.2001.n.006.CrossRefPubMed
65.
Sotlar K, Köveker G, Aepinus C, Selinka HC, Kandolf R, Bültmann B: Human papillomavirus type 16-associated primary squamous cell carcinoma of the rectum. Gastroenterology. 2001, 120: 988-994. 10.1053/gast.2001.22523.CrossRefPubMed
66.
Frizelle FA, Hobday KS, Batts KP, Nelson H: Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study. Dis Colon Rectum. 2001, 44: 341-346. 10.1007/BF02234730.CrossRefPubMed
67.
Kim N, Luchs JS, Halpern D, Davis E, Donovan V, Weston SR, Katz DS: Radiology-pathology conference: carcinosarcoma of the colon. J Clin Imag. 2005, 29: 259-262. 10.1016/j.clinimag.2004.09.002.CrossRef
68.
Lam AK, Ho YH: Primary squamous cell carcinoma of the rectum in a patient on immunosuppressive therapy. Pathology. 2006, 38: 74-76. 10.1080/00313020500467113.CrossRefPubMed
69.
Ambrosini-Spaltro A, Salvi F, Betts CM, Frezza GP, Piemontese A, Del Prete P, Baldoni C, Foschini MP, Viale G: Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy. Virchows Arch. 2006, 448: 442-448. 10.1007/s00428-005-0137-6.CrossRefPubMed
70.
Pikarsky AJ, Belin B, Efron J, Woodhouse S, Weiss EG, Wexner SD, Nogueras JJ: Squamous cell carcinoma of the rectum in ulcerative colitis: case report and review of the literature. Int J Colorectal Dis. 2007, 22: 445-447. 10.1007/s00384-006-0110-0.CrossRefPubMed
71.
Cheng H, Sitrin MD, Satchidanand SK, Novak JM: Colonic squamous cell carcinoma in ulcerative colitis: Report of a case and review of the literature. Can J Gastroenterol. 2007, 21: 47-50.CrossRefPubMedPubMedCentral
72.
Kong CS, Welton ML, Longacre TA: Role of human papillomavirus in squamous cell metaplasia-dysplasiacarcinoma of the rectum. Am J Surg Pathol. 2007, 31: 919-925. 10.1097/01.pas.0000213441.86030.fc.CrossRefPubMed
73.
Clark J, Cleator S, Goldin R, Lowdell C, Darzi A, Ziprin P: Treatment of primary rectal squamous cell carcinoma by primary chemoradiotherapy: should surgery still be considered a standard of care?. Eur J Cancer. 2008, 44: 2340-2343. 10.1016/j.ejca.2008.07.004.CrossRefPubMed
74.
Rasheed S, Yap T, Zia A, McDonald PJ, Glynne-Jones R: Chemo-radiotherapy: an alternative to surgery for squamous cell carcinoma of the rectum--report of six patients and literature review. Colorectal Dis. 2009, 11: 191-197. 10.1111/j.1463-1318.2008.01560.x.CrossRefPubMed
Metadata
Title
Squamous cell carcinoma of rectum presenting in a man: a case report
Authors
A Syed Sameer
Nidda Syeed
Nissar A Chowdri
Fazl Q Parray
Mushtaq A Siddiqi
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Medical Case Reports / Issue 1/2010
Electronic ISSN: 1752-1947
DOI
https://doi.org/10.1186/1752-1947-4-392

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