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01-04-2006 | Original Article

Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy

Authors: Andrea Ambrosini-Spaltro, Fabrizio Salvi, Christine M. Betts, Giovanni P. Frezza, Antonio Piemontese, Pietro Del Prete, Cristina Baldoni, Maria P. Foschini, Giuseppe Viale

Published in: Virchows Archiv | Issue 4/2006

Abstract

The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200–225 mg/m²) and 44–46 Gy in 22–23 fractions, were studied. All patients underwent biopsy before RCT. Surgery was performed within 6 weeks after RCT. In all cases oncocytic modifications were searched for on hematoxylin and eosin (H&E) and at immunohistochemistry using an antimitochondrial antibody. In addition, in two cases, both pre- and post-RCT tissues were examined at electron microscopy. All tumors were adenocarcinomas. In pre-RCT biopsies, oncocytic changes were difficult to find on H&E, while the antimitochondrial antibody strongly stained numerous neoplastic cells (mean 48.4%). In post-RCT surgical specimens, oncocytic changes were detected in 24 out of 28 cases on H&E and the antimitochondrial antibody stained most of the residual neoplastic cells (mean 76.7%). Ultrastructural examination revealed large and bizarre mitochondria inside tumor cells both in pre- and post-RCT tissues. In conclusion, the present data suggest that rectal adenocarcinomas are “mitochondrion-rich” tumors. After preoperative RCT, residual neoplastic cells acquire a definite oncocytic phenotype.

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Title: Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy
Authors: Andrea Ambrosini-Spaltro
Fabrizio Salvi
Christine M. Betts
Giovanni P. Frezza
Antonio Piemontese
Pietro Del Prete
Cristina Baldoni
Maria P. Foschini
Giuseppe Viale
Publication date: 01-04-2006
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 4/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0137-6

At a glance: The STEP trials

Springer Medicine

Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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