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Open Access 01-09-2013 | Poster presentation

Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice

Authors: François Mouton-Liger, Anne-Sophie Rebillat, Clarisse Pace, Sarah Gourmaud, Mariko Taga, Claire Paquet, Jacques Hugon

Published in: Molecular Neurodegeneration | Special Issue 1/2013

Excerpt

Systemic inflammation is correlated with dementia progression. Pro-inflammatory molecules can communicate from the periphery to the central nervous system to induce neuroinflammation and neurodegeneration. Our protein of interest is the pro-apoptotic kinase PKR (the double strand-RNA dependent protein kinase). Increased activated PKR levels were found in AD patients brain and cerebrospinal fluid. PKR activation can be triggered by inflammatory stresses and induces neurotoxicity in vitro. Is in vivo PKR-mediated inflammation involved in AD neurodegenerative process? …

Title: Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice
Authors: François Mouton-Liger
Anne-Sophie Rebillat
Clarisse Pace
Sarah Gourmaud
Mariko Taga
Claire Paquet
Jacques Hugon
Publication date: 01-09-2013
Publisher: BioMed Central
Published in: Molecular Neurodegeneration / Issue Special Issue 1/2013
Electronic ISSN: 1750-1326
DOI: https://doi.org/10.1186/1750-1326-8-S1-P32

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Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice

Excerpt

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