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Published in: Nutrition & Metabolism 1/2008

Open Access 01-12-2008 | Research

Effects of dairy intake on weight maintenance

Authors: Michael B Zemel, Joseph E Donnelly, Bryan K Smith, Debra K Sullivan, Joanna Richards, Danielle Morgan-Hanusa, Matthew S Mayo, Xiaocun Sun, Galen Cook-Wiens, Bruce W Bailey, Emily L Van Walleghen, Richard A Washburn

Published in: Nutrition & Metabolism | Issue 1/2008

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Abstract

Background

To compare the effects of low versus recommended levels of dairy intake on weight maintenance and body composition subsequent to weight loss.

Design and Methods

Two site (University of Kansas-KU; University of Tennessee-UT), 9 month, randomized trial. Weight loss was baseline to 3 months, weight maintenance was 4 to 9 months. Participants were maintained randomly assigned to low dairy (< 1 dairy serving/d) or recommended dairy (> 3 servings/d) diets for the maintenance phase. Three hundred thirty eight men and women, age: 40.3 ± 7.0 years and BMI: 34.5 ± 3.1, were randomized; Change in weight and body composition (total fat, trunk fat) from 4 to 9 months were the primary outcomes. Blood chemistry, blood pressure, resting metabolism, and respiratory quotient were secondary outcomes. Energy intake, calcium intake, dairy intake, and physical activity were measured as process evaluation.

Results

During weight maintenance, there were no overall significant differences for weight or body composition between the low and recommended dairy groups. A significant site interaction occurred with the low dairy group at KU maintaining weight and body composition and the low dairy group at UT increasing weight and body fat. The recommended dairy group exhibited reductions in plasma 1,25-(OH)2-D while no change was observed in the low dairy group. No other differences were found for blood chemistry, blood pressure or physical activity between low and recommended dairy groups. The recommended dairy group showed significantly greater energy intake and lower respiratory quotient compared to the low dairy group.

Conclusion

Weight maintenance was similar for low and recommended dairy groups. The recommended dairy group exhibited evidence of greater fat oxidation and was able to consume greater energy without greater weight gain compared to the low dairy group. Recommended levels of dairy products may be used during weight maintenance without contributing to weight gain compared to diets low in dairy products.

Trial Registration

ClinicalTrials.gov NCT00686426
Appendix
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Literature
1.
go back to reference Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006, 295: 1549-1555. 10.1001/jama.295.13.1549CrossRef Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 2006, 295: 1549-1555. 10.1001/jama.295.13.1549CrossRef
2.
go back to reference Weiss EC, Galuska DA, Khan LK, Serdula MK: Weight-control practices among U.S. adults, 2001–2002. Am J Prev Med 2006, 31: 18-24. 10.1016/j.amepre.2006.03.016CrossRef Weiss EC, Galuska DA, Khan LK, Serdula MK: Weight-control practices among U.S. adults, 2001–2002. Am J Prev Med 2006, 31: 18-24. 10.1016/j.amepre.2006.03.016CrossRef
3.
go back to reference Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC: Regulation of adiposity by dietary calcium. FASEB J 2000, 14: 1132-1138. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC: Regulation of adiposity by dietary calcium. FASEB J 2000, 14: 1132-1138.
4.
go back to reference Shi H, Dirienzo D, Zemel MB: Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB J 2001, 15: 291-293. Shi H, Dirienzo D, Zemel MB: Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB J 2001, 15: 291-293.
5.
go back to reference Zemel MB, Thompson W, Milstead A, Morris K, Campbell P: Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 2004, 12: 582-590. 10.1038/oby.2004.67CrossRef Zemel MB, Thompson W, Milstead A, Morris K, Campbell P: Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 2004, 12: 582-590. 10.1038/oby.2004.67CrossRef
6.
go back to reference Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E: Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond) 2005, 29: 391-397. 10.1038/sj.ijo.0802880CrossRef Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E: Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond) 2005, 29: 391-397. 10.1038/sj.ijo.0802880CrossRef
7.
go back to reference Zemel MB, Richards J, Milstead A, Campbell P: Effects of calcium and dairy on body composition and weight loss in African-American adults. Obes Res 2005, 13: 1218-1225. 10.1038/oby.2005.144CrossRef Zemel MB, Richards J, Milstead A, Campbell P: Effects of calcium and dairy on body composition and weight loss in African-American adults. Obes Res 2005, 13: 1218-1225. 10.1038/oby.2005.144CrossRef
8.
go back to reference Thompson WG, Rostad N, Janzow DJ, Slezak JM, Morris KL, Zemel MB: Effect of high dairy, high fiber, low glycemic index diets on obesity. Obesity Res 2005, 13: 1344-1353. 10.1038/oby.2005.163CrossRef Thompson WG, Rostad N, Janzow DJ, Slezak JM, Morris KL, Zemel MB: Effect of high dairy, high fiber, low glycemic index diets on obesity. Obesity Res 2005, 13: 1344-1353. 10.1038/oby.2005.163CrossRef
9.
go back to reference Lin YC, Lyle RM, McCabe LD, McCabe GP, Weaver CM, Teegarden D: Dairy calcium is related to changes in body composition during a two-year exercise intervention in young women. J Am Coll Nutr 2000, 19: 754-760.CrossRef Lin YC, Lyle RM, McCabe LD, McCabe GP, Weaver CM, Teegarden D: Dairy calcium is related to changes in body composition during a two-year exercise intervention in young women. J Am Coll Nutr 2000, 19: 754-760.CrossRef
10.
go back to reference Pereira MA, Jacobs DR, Horn LV, Slattery ML, Kartashov AI, Ludwig DS: Dairy consumption, obesity, and the insulin resistance syndrome in young adults. JAMA 2002, 287: 2081-2089. 10.1001/jama.287.16.2081CrossRef Pereira MA, Jacobs DR, Horn LV, Slattery ML, Kartashov AI, Ludwig DS: Dairy consumption, obesity, and the insulin resistance syndrome in young adults. JAMA 2002, 287: 2081-2089. 10.1001/jama.287.16.2081CrossRef
11.
go back to reference Caan B, Neuhouser M, Aragaki A, Lewis CB, Jackson R, LeBoff MS, et al.: Calcium plus vitamin D supplementation and the risk of postmenopausal weight gain. Arch Intern Med 2007, 167: 893-902. 10.1001/archinte.167.9.893CrossRef Caan B, Neuhouser M, Aragaki A, Lewis CB, Jackson R, LeBoff MS, et al.: Calcium plus vitamin D supplementation and the risk of postmenopausal weight gain. Arch Intern Med 2007, 167: 893-902. 10.1001/archinte.167.9.893CrossRef
12.
go back to reference Jacqmain M, Doucet E, Despres JP, Bouchard C, Tremblay A: Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am J Clin Nutr 2003, 77: 1448-1452. Jacqmain M, Doucet E, Despres JP, Bouchard C, Tremblay A: Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am J Clin Nutr 2003, 77: 1448-1452.
13.
go back to reference Loos RJ, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, et al.: Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study. J Nutr 2004, 134: 1772-1778. Loos RJ, Rankinen T, Leon AS, Skinner JS, Wilmore JH, Rao DC, et al.: Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study. J Nutr 2004, 134: 1772-1778.
14.
go back to reference Mirmiran P, Esmaillzadeh A, Azizi F: Dairy consumption and body mass index: an inverse relationship. Int J Obes 2005, 29: 115-121. 10.1038/sj.ijo.0802838CrossRef Mirmiran P, Esmaillzadeh A, Azizi F: Dairy consumption and body mass index: an inverse relationship. Int J Obes 2005, 29: 115-121. 10.1038/sj.ijo.0802838CrossRef
15.
go back to reference Shapses SA, Hesha S, Heymsfield SB: Effect of calcium supplementation on weight and fat loss in women. J Clin Endocrinol Metab 2004, 89: 632-637. 10.1210/jc.2002-021136CrossRef Shapses SA, Hesha S, Heymsfield SB: Effect of calcium supplementation on weight and fat loss in women. J Clin Endocrinol Metab 2004, 89: 632-637. 10.1210/jc.2002-021136CrossRef
16.
go back to reference Harvey-Berino J, Gold BC, Lauber R, Starinski A: The impact of calcium and dairy product consumption on weight loss. Obes Res 2005, 13: 1720-1726. 10.1038/oby.2005.210CrossRef Harvey-Berino J, Gold BC, Lauber R, Starinski A: The impact of calcium and dairy product consumption on weight loss. Obes Res 2005, 13: 1720-1726. 10.1038/oby.2005.210CrossRef
17.
go back to reference Bowen J, Noakes M, Clinfton PM: Effect of calcium and dairy foods in high protein, energy-restricted diets on weight loss and metabolic parameters in overweight adults. Int J Obes 2005, 29: 957-965. 10.1038/sj.ijo.0802895CrossRef Bowen J, Noakes M, Clinfton PM: Effect of calcium and dairy foods in high protein, energy-restricted diets on weight loss and metabolic parameters in overweight adults. Int J Obes 2005, 29: 957-965. 10.1038/sj.ijo.0802895CrossRef
18.
go back to reference Zemel MB: Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr 2004, 79: 907S-912S. Zemel MB: Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr 2004, 79: 907S-912S.
19.
go back to reference Shi H, Norman AW, Okamura WH, Sen A, Zemel MB: 1alpha,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes. FASEB J 2002, 16: 1808-1810. Shi H, Norman AW, Okamura WH, Sen A, Zemel MB: 1alpha,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes. FASEB J 2002, 16: 1808-1810.
20.
go back to reference Papakonstantinou E, Flatt WP, Huth PJ, Harris RBS: High dietary calcium reduces body fat content, digestibility of fat, and serum vitamen D in rats. Obes Res 2003, 11: 387-394. 10.1038/oby.2003.52CrossRef Papakonstantinou E, Flatt WP, Huth PJ, Harris RBS: High dietary calcium reduces body fat content, digestibility of fat, and serum vitamen D in rats. Obes Res 2003, 11: 387-394. 10.1038/oby.2003.52CrossRef
21.
go back to reference Jacobsen R, Lorenzen JK, Toubro S, Krog-Mikkelsen I, Astrup A: Effect of short-term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal fat excretion. Int J Obes Relat Metab Disord 2005, 29: 292-301. 10.1038/sj.ijo.0802785CrossRef Jacobsen R, Lorenzen JK, Toubro S, Krog-Mikkelsen I, Astrup A: Effect of short-term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal fat excretion. Int J Obes Relat Metab Disord 2005, 29: 292-301. 10.1038/sj.ijo.0802785CrossRef
22.
go back to reference Sun X, Zemel MB: Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids 2007, 42: 297-305. 10.1007/s11745-007-3029-5CrossRef Sun X, Zemel MB: Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells. Lipids 2007, 42: 297-305. 10.1007/s11745-007-3029-5CrossRef
23.
go back to reference Sun X, Zemel MB: Calcium and dairy products inhibit weight and fat regain during ad libitum cosumption following energy restriction in Ap2-agouti transgenic mice. J Nutr 2004, 134: 3054-3060. Sun X, Zemel MB: Calcium and dairy products inhibit weight and fat regain during ad libitum cosumption following energy restriction in Ap2-agouti transgenic mice. J Nutr 2004, 134: 3054-3060.
24.
go back to reference Garner DM, Olmsted MP, Bohr Y, Garfinkel PE: The eating attitudes test: psychometric features and clinical correlates. Psychol Med 1982, 12: 871-878.CrossRef Garner DM, Olmsted MP, Bohr Y, Garfinkel PE: The eating attitudes test: psychometric features and clinical correlates. Psychol Med 1982, 12: 871-878.CrossRef
25.
go back to reference Strunkard AJ, Messick S: The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 1985, 29: 71-83. 10.1016/0022-3999(85)90010-8CrossRef Strunkard AJ, Messick S: The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 1985, 29: 71-83. 10.1016/0022-3999(85)90010-8CrossRef
26.
go back to reference Radloff LS: The CED-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977, 1: 395-401. 10.1177/014662167700100306CrossRef Radloff LS: The CED-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977, 1: 395-401. 10.1177/014662167700100306CrossRef
27.
go back to reference Fulgoni VL 3rd, Huth PJ, DiRienzo DB, Miller GD: Determination of the optimal number of dairy servings to ensure a low prevalence of inadequate calcium intake in Americans. J Am Coll Nutr 2004, 23: 651-659.CrossRef Fulgoni VL 3rd, Huth PJ, DiRienzo DB, Miller GD: Determination of the optimal number of dairy servings to ensure a low prevalence of inadequate calcium intake in Americans. J Am Coll Nutr 2004, 23: 651-659.CrossRef
28.
go back to reference Bailey BW, Sullivan DK, Kirk E, Hall S, Donnelly JE: The influence of claicum consumption on weight and fat following 9 months of exercise in men and women. J Am Coll Nutr 2007, 26: 350-355.CrossRef Bailey BW, Sullivan DK, Kirk E, Hall S, Donnelly JE: The influence of claicum consumption on weight and fat following 9 months of exercise in men and women. J Am Coll Nutr 2007, 26: 350-355.CrossRef
29.
go back to reference Lohman TG, Roche AF, Martorell R: Anthropometric standardization reference manual. Human Kinetics Books: Champaign, Ill; 1988. Lohman TG, Roche AF, Martorell R: Anthropometric standardization reference manual. Human Kinetics Books: Champaign, Ill; 1988.
30.
go back to reference Burnstein M, Scholnick HR, Morfin R: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970, 11: 583-595. Burnstein M, Scholnick HR, Morfin R: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970, 11: 583-595.
31.
go back to reference Morgan CR, Larner J: Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic rats. Diabetes 1963, 12: 115-126.CrossRef Morgan CR, Larner J: Immunoassay of insulin: two antibody system: plasma insulin levels of normal, subdiabetic rats. Diabetes 1963, 12: 115-126.CrossRef
32.
go back to reference Voors AW, Foster TA, Frerichs RR, Webber LS, Berenson GS: Studies of blood pressures in children, ages 5–14, in a total biracial community, the Bogalusa heart study. Circulation 1976, 54: 319-327.CrossRef Voors AW, Foster TA, Frerichs RR, Webber LS, Berenson GS: Studies of blood pressures in children, ages 5–14, in a total biracial community, the Bogalusa heart study. Circulation 1976, 54: 319-327.CrossRef
33.
go back to reference Elkasabany AM, Urbina EM, Daniels SR, Berenson GS: Prediction of adult hypertension by K4 and K5 diastolic blood pressure in children: the Bogalusa heart study. J Pediatrics 1998, 132: 687-692. 10.1016/S0022-3476(98)70361-0CrossRef Elkasabany AM, Urbina EM, Daniels SR, Berenson GS: Prediction of adult hypertension by K4 and K5 diastolic blood pressure in children: the Bogalusa heart study. J Pediatrics 1998, 132: 687-692. 10.1016/S0022-3476(98)70361-0CrossRef
34.
go back to reference Luepker RV, Jacobs DR, Prineas RJ, Sinaiko AR: Secular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986 to 1996. J Pediatrics 1999, 134: 668-674. 10.1016/S0022-3476(99)70279-9CrossRef Luepker RV, Jacobs DR, Prineas RJ, Sinaiko AR: Secular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986 to 1996. J Pediatrics 1999, 134: 668-674. 10.1016/S0022-3476(99)70279-9CrossRef
35.
go back to reference U.S. Department of Health and Human Services: The 1988 report of the Joint National Committee on detection, evaluation and treatment of high blood pressure. U.S. Government, NIH Publication No. 88-1088: Washington, D.C; 1988. U.S. Department of Health and Human Services: The 1988 report of the Joint National Committee on detection, evaluation and treatment of high blood pressure. U.S. Government, NIH Publication No. 88-1088: Washington, D.C; 1988.
36.
go back to reference Consolazio CF, Johnston RE, Pecora LJ: Physiological measurements of metabolic functions in man. McGraw-Hill: New York, NY; 1963. Consolazio CF, Johnston RE, Pecora LJ: Physiological measurements of metabolic functions in man. McGraw-Hill: New York, NY; 1963.
37.
go back to reference Weir JB: New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949, 109: 1-9.CrossRef Weir JB: New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949, 109: 1-9.CrossRef
38.
go back to reference Jequier E, Acheson K, Schutz Y: Assessment of energy expenditure and fuel utilization in man. Annu Rev Nutr 1987, 7: 187-208. 10.1146/annurev.nu.07.070187.001155CrossRef Jequier E, Acheson K, Schutz Y: Assessment of energy expenditure and fuel utilization in man. Annu Rev Nutr 1987, 7: 187-208. 10.1146/annurev.nu.07.070187.001155CrossRef
39.
go back to reference Gunther CW, Lyle RM, Legowski PA, James JM, McCabe LD, McCabe GP, et al.: Fat oxidation and its relation to serum parathyroid hormone in young women enrolled in a 1-y dairy calcium intervention. Am J Clin Nutr 2005, 82: 1228-1234. Gunther CW, Lyle RM, Legowski PA, James JM, McCabe LD, McCabe GP, et al.: Fat oxidation and its relation to serum parathyroid hormone in young women enrolled in a 1-y dairy calcium intervention. Am J Clin Nutr 2005, 82: 1228-1234.
40.
go back to reference Melanson EL, Donahoo WT, Dong F, Ida T, Zemel MB: Effect of low- and high-calcium dairy-based diets on macronutrient oxidation in humans. Obes Res 2005, 13: 2102-2112. 10.1038/oby.2005.261CrossRef Melanson EL, Donahoo WT, Dong F, Ida T, Zemel MB: Effect of low- and high-calcium dairy-based diets on macronutrient oxidation in humans. Obes Res 2005, 13: 2102-2112. 10.1038/oby.2005.261CrossRef
41.
go back to reference Westerterp-Plantenga MS: The significance of protein in food intake and body weight regulation. Curr Opin Clin Nutr Metab Care 2003, 6: 635-638. 10.1097/00075197-200311000-00005CrossRef Westerterp-Plantenga MS: The significance of protein in food intake and body weight regulation. Curr Opin Clin Nutr Metab Care 2003, 6: 635-638. 10.1097/00075197-200311000-00005CrossRef
42.
go back to reference Latner JD, Schwartz M: The effects of a high-carbohydrate, high-protein or balanced lunch upon later food intake and hunger ratings. Appetite 1999, 33: 119-128. 10.1006/appe.1999.0237CrossRef Latner JD, Schwartz M: The effects of a high-carbohydrate, high-protein or balanced lunch upon later food intake and hunger ratings. Appetite 1999, 33: 119-128. 10.1006/appe.1999.0237CrossRef
43.
go back to reference Pedersen NL, Nagain-Domaine C, Mahe S, Chariot J, Roze C, Tome D: Caseinomacropeptide specifically stimulates exocrine pancreatic secretion in the anesthetized rat. Peptides 2000, 21: 1527-1535. 10.1016/S0196-9781(00)00307-7CrossRef Pedersen NL, Nagain-Domaine C, Mahe S, Chariot J, Roze C, Tome D: Caseinomacropeptide specifically stimulates exocrine pancreatic secretion in the anesthetized rat. Peptides 2000, 21: 1527-1535. 10.1016/S0196-9781(00)00307-7CrossRef
44.
go back to reference Hollis JH, Mattes RD: Effect of increased dairy consumption on appetitive ratings and food intake. Obesity (Silver Spring) 2007, 15: 1520-1526. 10.1038/oby.2007.180CrossRef Hollis JH, Mattes RD: Effect of increased dairy consumption on appetitive ratings and food intake. Obesity (Silver Spring) 2007, 15: 1520-1526. 10.1038/oby.2007.180CrossRef
45.
go back to reference Ochner CN, Lowe MR: Self-Reported Changes in Dietary Calcium and Energy Intake Predict Weight Regain following a Weight Loss Diet in Obese Women. J Nutr 2007, 137: 2324-2328. Ochner CN, Lowe MR: Self-Reported Changes in Dietary Calcium and Energy Intake Predict Weight Regain following a Weight Loss Diet in Obese Women. J Nutr 2007, 137: 2324-2328.
Metadata
Title
Effects of dairy intake on weight maintenance
Authors
Michael B Zemel
Joseph E Donnelly
Bryan K Smith
Debra K Sullivan
Joanna Richards
Danielle Morgan-Hanusa
Matthew S Mayo
Xiaocun Sun
Galen Cook-Wiens
Bruce W Bailey
Emily L Van Walleghen
Richard A Washburn
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Nutrition & Metabolism / Issue 1/2008
Electronic ISSN: 1743-7075
DOI
https://doi.org/10.1186/1743-7075-5-28

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