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AIDS Research and Therapy
Published in: AIDS Research and Therapy 1/2005

Open Access 01-12-2005 | Short report

HIV in semen: Still more to be learned

Author: Pietro L Vernazza

Published in: AIDS Research and Therapy | Issue 1/2005

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Excerpt

In 1983, during the earliest days of AIDS research, Deborah Anderson and her colleagues in Boston, Massachusetts hypothesized that AIDS was transmitted by virally-infected "Trojan horse leukocytes" in semen [1]. This prediction has been supported by numerous studies over the past two decades, although many questions remain concerning HIV infection of the male genital tract. In this issue of AIDS Research and Therapy, the Anderson group presents an important research tool to help address some of the critical unanswered questions in this area [2]. …
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Stewart GJ, Tyler JP, Cunningham AL, Barr JA, Driscoll GL, Gold J, Lamont BJ: Transmission of human T-cell lymphotropic virus type III (HTLV- III) by artificial insemination by donor. Lancet. 1985, 2: 581-585. 10.1016/S0140-6736(85)90585-9CrossRefPubMed
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Quayle AJ, Xu C, Mayer KH, Anderson DJ: T lymphocytes and macrophages, but not motile spermatozoa, are a signi ficant source of human immunodeficiency virus in semen. J Infect Dis. 1997, 176: 960-968.CrossRefPubMed
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Semprini AE, Vucetich A, Hollander L: Sperm washing, use of HAART and role of elective Caesarean section. Curr Opin Obstet Gynecol. 2004, 16: 465-470. 10.1097/00001703-200412000-00005CrossRefPubMed
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Vernazza PL, Gilliam BL, Dyer JR, Fiscus SA, Eron JJ, Frank AC, Cohen MS: Quantitation of HIV in semen: Correlation with antiviral treatment and immune status. AIDS. 1997, 11: 987-993. 10.1097/00002030-199708000-00006CrossRefPubMed
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Cohen MS, Hoffman IF, Royce RA, Kazembe P, Dyer JR, Daly CC, Zimba D, Vernazza PL, Maida M, Fiscus SA, Eron JJJ: Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. Lancet. 1997, 349: 1868-1873. 10.1016/S0140-6736(97)02190-9CrossRefPubMed
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Vernazza PL, Troiani L, Flepp MJ, Cone RW, Schock J, Roth F, Boggian K, Cohen MS, Fiscus SA, Eron JJ: Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. The Swiss HIV Cohort Study. AIDS. 2000, 14: 117-121. 10.1097/00002030-200001280-00006CrossRefPubMed
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Eron JJ, Vernazza PL, Johnston DM, Seillier-Moiseiwitsch F, Alcorn TM, Fiscus SA, Cohen MS: Resistance to HIV-1 to antiretroviral agents in blood and seminal plasma: Implications for Transmission. AIDS. 1998, 12: F189-CrossRef
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Metadata
Title
HIV in semen: Still more to be learned
Author
Pietro L Vernazza
Publication date
01-12-2005
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2005
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/1742-6405-2-11

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Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

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