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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2013

Open Access 01-12-2013 | Review

Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury

Authors: Huang Fang, Peng-Fei Wang, Yu Zhou, Yan-Chun Wang, Qing-Wu Yang

Published in: Journal of Neuroinflammation | Issue 1/2013

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Abstract

Intracerebral hemorrhage (ICH) is a common type of fatal stroke, accounting for about 15% to 20% of all strokes. Hemorrhagic strokes are associated with high mortality and morbidity, and increasing evidence shows that innate immune responses and inflammatory injury play a critical role in ICH-induced neurological deficits. However, the signaling pathways involved in ICH-induced inflammatory responses remain elusive. Toll-like receptor 4 (TLR4) belongs to a large family of pattern recognition receptors that play a key role in innate immunity and inflammatory responses. In this review, we summarize recent findings concerning the involvement of TLR4 signaling in ICH-induced inflammation and brain injury. We discuss the key mechanisms associated with TLR4 signaling in ICH and explore the potential for therapeutic intervention by targeting TLR4 signaling.
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Metadata
Title
Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury
Authors
Huang Fang
Peng-Fei Wang
Yu Zhou
Yan-Chun Wang
Qing-Wu Yang
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2013
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/1742-2094-10-27

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