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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2004

Open Access 01-12-2004 | Research

Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors

Authors: Susanna Rosi, Victor Ramirez-Amaya, Beatrice Hauss-Wegrzyniak, Gary L Wenk

Published in: Journal of Neuroinflammation | Issue 1/2004

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Abstract

Background

Neuroinflammation plays a prominent role in the progression of Alzheimer's disease and may be responsible for degeneration in vulnerable regions such as the hippocampus. Neuroinflammation is associated with elevated levels of extracellular glutamate and potentially an enhanced stimulation of glutamate N-methyl-D-aspartate receptors. This suggests that neurons that express these glutamate receptors might be at increased risk of degeneration in the presence of chronic neuroinflammation.

Methods

We have characterized a novel model of chronic brain inflammation using a slow infusion of lipopolysaccharide into the 4th ventricle of rats. This model reproduces many of the behavioral, electrophysiological, neurochemical and neuropathological changes associated with Alzheimer's disease.

Results

The current study demonstrated that chronic neuroinflammation is associated with the loss of N-methyl-D-aspartate receptors, as determined both qualitatively by immunohistochemistry and quantitatively by in vitro binding studies using [3H]MK-801, within the hippocampus and entorhinal cortex.

Conclusion

The gradual loss of function of this critical receptor within the temporal lobe region may contribute to some of the cognitive deficits observed in patients with Alzheimer's disease.
Appendix
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Metadata
Title
Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors
Authors
Susanna Rosi
Victor Ramirez-Amaya
Beatrice Hauss-Wegrzyniak
Gary L Wenk
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2004
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/1742-2094-1-12

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