Published in:
Open Access
01-11-2010 | Poster presentation
A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with Systemic Sclerosis in a large European cohort
Authors:
L Bossini-Castillo, JCA Broen, C P Simeon, L Beretta, M C Vonk, N Ortego-Centeno, G Espinosa, P Carreira, M T Camps, N Navarrete, M F González-Escribano, E Vicente-Rabaneda, L Rodríguez, C Tolosa, J A Román-Ivorra, I Gómez-Gracia, F J García-Hernández, I Castellví, M Gallego, A Fernández-Nebro, M V Egurbide, V Follonosa, P García de la Peña, A Pros, M A González-Gay, R Hesselstrand, G Riemekasten, T Witte, MJH Coenen, B P Koeleman, F Houssiau, V Smith, F De Keyser, R Westhovens, E De Langhe, A E Voskuyl, A J Schuerwegh, M M Chee, R Madhok, P Shiels, C Fonseca, C Denton, K Claes, L Padykov, A Nordin, Ø Palm, B A Lie, P Airó, R Scorza, J M van Laar, N Hunzelmann, A Kreuter, A Herrick, J Worthington, TRDJ Radstake, J Martín, B Rueda
Published in:
Journal of Translational Medicine
|
Special Issue 1/2010
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Excerpt
The
TNFSF4 gene, which encodes OX40L, is considered as a potential autoimmunity candidate gene. OX40L is expressed on activated antigen presenting cells (APCs) and endothelial cells in acute inflammation [
1]. Furthermore, it enhances B-cell proliferation and differentiation, and its binding to OX40 (CD134) promotes proliferation and survival of T-cells and predisposes them to a more permissive proliferative and survival condition [
2]. Interestingly, four
TNFSF4 promoter single-nucleotide polymorphisms (SNP) were recently implicated in susceptibility to systemic sclerosis (SSc)[
3]. …
