Published in:
Open Access
01-11-2010 | Poster presentation
Identification of distinct polarized macrophage subsets in inflammatory arthritis
Authors:
C Ambarus, S Krausz, J Hamann, M H Wenink, TRDJ Radstake, P P Tak, D Baeten
Published in:
Journal of Translational Medicine
|
Special Issue 1/2010
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Excerpt
The concept of macrophage polarization describes the heterogeneity of activated macrophages under specific microenvironmental conditions. Based on their pro- or anti-inflammatory functions, M1 and M2 macrophages have been described. We aim to assess type 2 inflammation in spondyloarthritis (SpA) versus type 1 inflammation in rheumatoid arthritis (RA). Here, we investigated the expression of cell surface molecules on in vitro differentiated human macrophages. …