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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Poster presentation

Single-cell gene profiling analysis of human regulatory T cell subsets

Authors: S Maiella, S Dong, C Becavin, M Coffre, K Placek, E Bianchi, A Benecke, L Rogge

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

Negative regulation of the immune system is of critical importance to prevent pathology. This level of regulation is compromised in autoimmunity and graft-versus-host disease, a life-threatening complication of hematopoietic stem cell transplantation. CD4+CD25+FOXP3+ regulatory T cells (Treg) are potent suppressors of these adverse immune reactions. Treg also play critical roles in the maintenance self-tolerance and the control of immune homeostasis. Recent reports have suggested that human Treg cells may not be a homogenous cell population. …
Metadata
Title
Single-cell gene profiling analysis of human regulatory T cell subsets
Authors
S Maiella
S Dong
C Becavin
M Coffre
K Placek
E Bianchi
A Benecke
L Rogge
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-P3

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