Published in:
Open Access
01-11-2010 | Poster presentation
Painful myositis in the anti-synthetase syndrome with anti-PL12 antibodies
Authors:
P Mehta, L Patel, F Roncaroli, M C Pickering, A Brand
Published in:
Journal of Translational Medicine
|
Special Issue 1/2010
Login to get access
Excerpt
The idiopathic inflammatory myopathies (IIMs) are characterized by muscle weakness, electromyography (EMG), histological and biochemical features of muscle inflammation. Their classification is evolving due to the myositis-associated autoantibody panel. Anti-aminoacyl-tRNA synthetase (ARS) antibodies are detected in 25-30% patients and define the anti-synthetase syndrome (ASS), a spectrum of interstitial lung disease (ILD), arthritis, fever, Raynaud’s phenomenon and mechanic’s hands. Anti-Jo1 antibodies are most common (20%), whereas anti-PL12 antibodies (alanyl-tRNA synthetase) occur in <3% cases. …