Published in:
Open Access
01-11-2010 | Poster presentation
Perivascular adipocytes and signaling through toll-like receptors: role in the pathophysiology of atherosclerosis
Authors:
C Benaiges, X Garcia-Moll, E Mateus, C Muñoz, E Cantó, E Pérez, R Leta, E Moga, S Vidal, C Juarez
Published in:
Journal of Translational Medicine
|
Special Issue 1/2010
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Excerpt
Perivascular adipose tissue has emerged as a critical regulator of vascular function implicated in the pathophysiology of atherosclerosis. Virtually all arteries are surrounded by a significant amount of perivascular adipose tissue. This tissue is a very active endocrine and paracrine source of inflammatory cytokines and adipokines. Moreover, adipocytes express toll-like receptors (TLRs) to be able to respond to lipids and other self and nonself molecules activating proinflammatory pathways. We analyze the TLR/JAK-STAT/SOCS transduction pathways in adipose tissue from patients with atherosclerosis to unravel the mechanisms implicated in the pathophysiology of atherosclerosis. …
