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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Poster presentation

The neonatal Fc receptor is expressed by human lymphocytes

Authors: K van Bilsen, J Bastiaans, W A Dik, E F De Haas, S G Baarsma, R W Kuipers, P M van Hagen

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

The neonatal Fc receptor (FcRn) is an MHC class I like receptor that binds immunoglobulin G (IgG) in acidic environment (mainly endosomes). The FcRn protects IgG from lysosomal degradation, controls its transport between cell layers and extends IgG serum half-life [1]. It has been shown that the FcRn is expressed by many human cells including APCs and monocytes [2]. Thus far FcRn expression by human lymphocytes has not been proven. …
Literature
1.
Roopenian DC, Akilesh S: FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol. 2007, 7 (9): 715-25. 10.1038/nri2155.CrossRefPubMed
2.
Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, Miao L, Wang Y, Robert C, Wu B, Smith PD, Lencer WI, Blumberg RS: MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol. 2001, 166 (5): 3266-76.PubMedCentralCrossRefPubMed
Metadata
Title
The neonatal Fc receptor is expressed by human lymphocytes
Authors
K van Bilsen
J Bastiaans
W A Dik
E F De Haas
S G Baarsma
R W Kuipers
P M van Hagen
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-P1

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