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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2010

Open Access 01-11-2010 | Invited lecture presentation

Chemokines as inflammatory mediators of fibrosis in liver fibrosis

Author: H E Wasmuth

Published in: Journal of Translational Medicine | Special Issue 1/2010

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Excerpt

Chemokines are a class of small heparin-binding molecules which orchestrate the infiltration of leukocyte subsets into the liver during acute and chronic injury. In experimental models of liver fibrosis, chemokines are secreted by liver resident (e.g. hepatocytes, stellate cells) and liver infiltrating cells (e.g. leukocytes, platelets). Chemokines bind to characteristic G-protein coupled transmembraneous receptors which are also widely distributed within the liver. …
Metadata
Title
Chemokines as inflammatory mediators of fibrosis in liver fibrosis
Author
H E Wasmuth
Publication date
01-11-2010
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue Special Issue 1/2010
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-8-S1-I13

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