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Open Access 01-12-2003 | Review

Angiogenesis in the corpus luteum

Authors: Hamish M Fraser, Christine Wulff

Published in: Reproductive Biology and Endocrinology | Issue 1/2003

Abstract

The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor (VEGF) has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase in vivo by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.

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Title: Angiogenesis in the corpus luteum
Authors: Hamish M Fraser
Christine Wulff
Publication date: 01-12-2003
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2003
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/1477-7827-1-88

ACC 2024 Congress

Springer Medicine

Angiogenesis in the corpus luteum

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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