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Open Access 01-12-2011 | Research

Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer

Authors: Zi-Yu Li, Fei Shan, Lian-Hai Zhang, Zhao-De Bu, Ai-Wen Wu, Xiao-Jiang Wu, Xiang-Long Zong, Qi Wu, Hui Ren, Jia-Fu Ji

Published in: World Journal of Surgical Oncology | Issue 1/2011

Abstract

Background

This study assessed the postoperative morbidity and mortality occurring in the first 30 days after radical gastrectomy by comparing gastric cancer patients who did or did not receive the FOLFOX7 regimen of neoadjuvant chemotherapy.

Methods

We completed a retrospective analysis of 377 patients after their radical gastrectomies were performed in our department between 2005 and 2009. Two groups of patients were studied: the SURG group received surgical treatment immediately after diagnosis; the NACT underwent surgery after 2-6 cycles of neoadjuvant chemotherapy.

Results

There were 267 patients in the SURG group and 110 patients in the NACT group. The NACT group had more proximal tumours (P = 0.000), more total/proximal gastrectomies (P = 0.000) and longer operative time (P = 0.005) than the SURG group. Morbidity was 10.0% in the NACT patients and 17.2% in the SURG patients (P = 0.075). There were two cases of postoperative death, both in the SURG group (P = 1.000). No changes in complications or mortality rate were observed between the SURG and NACT groups.

Conclusion

The FOLFOX7 neoadjuvant chemotherapy is not associated with increased postoperative morbidity, indicating that the FOLFOX7 neoadjuvant chemotherapy is a safe choice for the treatment of local advanced gastric cancer.

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Title: Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer
Authors: Zi-Yu Li
Fei Shan
Lian-Hai Zhang
Zhao-De Bu
Ai-Wen Wu
Xiao-Jiang Wu
Xiang-Long Zong
Qi Wu
Hui Ren
Jia-Fu Ji
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2011
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-9-110

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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