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World Journal of Surgical Oncology

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Open Access 01-12-2013 | Research

Differences in risk factors between patterns of recurrence in patients after curative resection for advanced gastric carcinoma

Authors: Yoshitsugu Nakanishi, Masanori Ohara, Hiromitsu Domen, Toshiaki Shichinohe, Satoshi Hirano, Masanori Ishizaka

Published in: World Journal of Surgical Oncology | Issue 1/2013

Abstract

Background

Recurrence patterns in patients who have undergone curative gastrectomy for advanced gastric carcinoma can be classified as peritoneal, hematogenous, or lymphatic. The aim of this study was to clarify differences in risk factors between these different types of recurrence pattern.

Methods

Postoperative courses, including sites of recurrence and periods between surgery and recurrence, of patients who had undergone curative gastrectomy for advanced gastric carcinoma (more than pT2 invasion) were surveyed in detail. Clinicopathological factors were examined as potential independent risk factors for each recurrence pattern, based on recurrence-free survival, using multivariate analysis.

Results

Multivariate analysis identified depth of tumor invasion (pT4 vs. pT2/3; hazard ratio (HR), 7.05; P < 0.001), number of lymph node metastases (pN2/3 vs. pN0/1; HR, 4.02; P = 0.001), and histological differentiation (G3/4 vs. G1/2; HR, 2.22; P = 0.041) as independent risk factors for peritoneal metastasis. The number of lymph node metastases (HR, 26.21; P < 0.001) and venous vessel invasion (HR, 5.09; P = 0.001) were identified as independent risk factors for hematogenous metastasis. The number of lymph node metastases (HR, 6.00; P = 0.007) and depth of tumor invasion (HR, 4.70; P = 0.023) were identified as independent risk factors for lymphatic metastasis.

Conclusions

This study clarified differences in risk factors between various patterns of recurrence. Careful examination of risk factors could help prevent oversight of recurrences and improve detection of recurrences during follow-up. The number of lymph node metastases represents an independent risk factor for all three patterns of recurrence; thus, patients with multiple lymph node metastases warrant particular attention.

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Title: Differences in risk factors between patterns of recurrence in patients after curative resection for advanced gastric carcinoma
Authors: Yoshitsugu Nakanishi
Masanori Ohara
Hiromitsu Domen
Toshiaki Shichinohe
Satoshi Hirano
Masanori Ishizaka
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2013
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-11-98

ACC 2024 Congress

Springer Medicine

Differences in risk factors between patterns of recurrence in patients after curative resection for advanced gastric carcinoma

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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