Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2012

Open Access 01-12-2012 | Case report

Myxofibrosarcoma of the sinus piriformis: case report and literature review

Authors: Zhu Qiubei, Lin Cheng, Xu Yaping, Lin Shunzhang, Fan Jingping

Published in: World Journal of Surgical Oncology | Issue 1/2012

Login to get access

Abstract

Myxofibrosarcoma is a common sarcoma in the extremities of older people, but is rare in the head and neck region. Here, we report the case of a 42-year-old male patient in whom myxofibrosarcoma generated from the sinus piriformis. Histopathologically, the tumor was characterized by spindle cellular proliferation with moderate cellular density in fibromyxoid stroma. Immunohistochemically, the tumor cells showed positive reactivity for vimentin, Ki-67, smooth muscle actin, and CD34, but negative staining for S-100. Based on these results, the tumor was diagnosed as a low-grade myxofibrosarcoma. Resection of the tumor was performed via a transcervical approach. The patient’s postoperative clinical course was uneventful and no local recurrence or distant metastasis has been found so far. The pathology, clinical characteristics, and treatment of myxofibrosarcoma are also reviewed.
Appendix
Available only for authorised users
Literature
1.
Udaka T, Yamamoto H, Shiomori T, Fujimura T, Suzuki H: Myxofibrosarcoma of the neck. J Laryngol Otol. 2006, 120: 872-874.CrossRefPubMed
2.
Prasad I, Sharan R: Myxofibrosarcoma of larynx. Indian J Otolaryngol Head Neck Surg. 1981, 33 (2): 71-71.
3.
Song HK, Miller JI: Primary myxofibrosarcoma of the esophagus. J Thorac Cardiovasc Surg. 2002, 124 (1): 196-197. 10.1067/mtc.2002.122818.CrossRefPubMed
4.
Enomoto K, Inohara H, Hamada K, Tamura M, Tomita Y, Kubo T, Hatazawa J: FDG PET imaging of myxofibrosarcoma on the sphenoid sinus. Clin Nucl Med. 2008, 33 (6): 421-422. 10.1097/RLU.0b013e318170d51a.CrossRefPubMed
5.
Lam PK, Trendell-Smith N, Li JH, Fan YW, Yuen AP: Myxofibrosarcoma of the sphenoid sinus. J Laryngol Otol. 2002, 116 (6): 464-466.CrossRefPubMed
6.
Zouloumis L, Ntomouchtsis A, Lazaridis N: Giant myxofibrosarcoma of the mandible. Balkan Journal of Stomatology. 2010, 14 (1): 41-44.
7.
Norval EJG, Raubenheimer EJ: Myxofibrosarcoma arising in the maxillary sinus: a case report with a review of the ultrastructural findings and differential diagnoses. J Maxillofac Oral Surg. 2011, 10: 334-339. 10.1007/s12663-011-0259-0.PubMedCentralCrossRefPubMed
8.
Li X, Chen X, Shi ZH, Chen Y, Ye J, Qiao L, Qiu JH: Primary myxofibrosarcoma of the parotid: case report. BMC Cancer. 2010, 10: 246-10.1186/1471-2407-10-246.PubMedCentralCrossRefPubMed
9.
Srinivasan B, Ethunandan M, Hussain K, Ilankovan V: Epitheloid myxofibrosarcoma of the parotid gland. Case Report Pathol. 2011, 2011: 641621-
10.
Zhang Q, Wojno TH, Yaffe B, Grossniklaus HE: Myxofibrosarcoma of the orbit. Ophthal Plast Reconstr Surg. 2010, 26 (2): 129-10.1097/IOP.0b013e3181b8efee.PubMedCentralCrossRefPubMed
11.
Imai Y, Sugawara Y, Okazaki M, Harii K: Low grade myxofibrosarcoma in the orbit: a case report. Japanese J Plastic Reconstructive Surg. 2000, 43 (4): 401-409.
12.
Krishnamurthy A, Vaidhyanathan A, Majhi U: Myxofibrosarcoma of the infratemporal space. J Cancer Res Ther. 2011, 7 (2): 185-10.4103/0973-1482.82913.CrossRefPubMed
13.
Nishimura G, Sano D, Hanashi M, Yamanaka S, Tanigaki Y, Taguchi T, Horiuchi C, Matsuda H, Mikami Y, Tsukuda M: Myxofibrosarcoma of the hypopharynx. Auris Nasus Larynx. 2006, 33 (1): 93-96. 10.1016/j.anl.2005.07.004.CrossRefPubMed
14.
Al-Agha OM, Igbokwe AA: Malignant fibrous histiocytoma: between the past and the present. Arch Pathol Lab Med. 2008, 132 (6): 1030-1035.PubMed
15.
Enjoji M, Hashimoto H, Tsuneyoshi M, Iwasaki H: Malignant fibrous histiocytoma. Pathol Int. 1980, 30 (5): 727-741. 10.1111/j.1440-1827.1980.tb00970.x.CrossRef
16.
Park SW, Kim HJ, Lee J, Ko YH: Malignant fibrous histiocytoma of the head and neck: CT and MR imaging findings. Am J Neuroradiol. 2009, 30 (1): 71-76.CrossRefPubMed
17.
Matushansky I, Charytonowicz E, Mills J, Siddiqi S, Hricik T, Cordon-Cardo C: MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st century. Expert Rev Anticancer Ther. 2009, 9 (8): 1135-10.1586/era.09.76.PubMedCentralCrossRefPubMed
18.
Angervall L, Kindblom LG, Merck C: Myxofibrosarcoma. A study of 30 cases. Acta Pathol Microbiol Scand A. 1977, 85 (2): 127-140.
19.
Pathology and Genetics of Tumours of Soft Tissue and Bone. Edited by: Fletcher CDM, Unni KK, Mertens F. 2002, Lyon: IARC Press
20.
Blitzer A, Lawson W, Zak FG, Biller HF, Som ML: Clinical‐pathological determinants in prognosis of fibrous histiocytomas of head and neck. Laryngoscope. 1981, 91 (12): 2053-2070.CrossRefPubMed
21.
Pomerantz J, Sanfacon D, Dougherty T, Hanson S: Myxofibrosarcoma of the maxillary sinus. Del Med J. 1982, 54 (3): 147-152.PubMed
22.
Barnes L, Kanbour A: Malignant fibrous histiocytoma of the head and neck: a report of 12 cases. Arch Otolaryngol Head Neck Surg. 1988, 114 (10): 1149-1156. 10.1001/archotol.1988.01860220083030.CrossRefPubMed
23.
Nishio J, Iwasaki H, Nabeshima K, Naito M: Cytogenetics and molecular genetics of myxoid soft-tissue sarcomas. Genet Res Int. 2011, 2011: 497148-PubMedCentralPubMed
24.
Iguchi Y, Takahashi H, Yao K, Nakayama M, Nagai H, Okamoto M: Malignant fibrous histiocytoma of the nasal cavity and paranasal sinuses: review of the last 30 years. Acta Otolaryngol Suppl. 2002, 122 (4): 75-78. 10.1080/000164802760057635.CrossRef
25.
Enoz M, Suoglu Y: Myxofibrosarcoma of the maxillary sinus. Internet J Head Neck Surg. 2007, 1 (1): 1-4.
26.
Gugatschka M, Beham A, Stammberger H, Schmid C, Friedrich G: First case of a myxofibrosarcoma of the vocal folds: case report and review of the literature. J Voice. 2010, 24 (3): 374-376. 10.1016/j.jvoice.2008.10.008.CrossRefPubMed
27.
Nakahara S, Uemura H, Kurita T, Suzuki M, Fujii T, Tomita Y, Yoshino K: A case of myxofibrosarcoma of the maxilla with difficulty in preoperative diagnosis. Int J Clinical Oncol. 2012, 17: 390-394. 10.1007/s10147-011-0302-7.CrossRef
28.
Merck C, Angervall L, Kindblom LG, Odén A: Myxofibrosarcoma. A malignant soft tissue tumor of fibroblastic-histiocytic origin. A clinicopathologic and prognostic study of 110 cases using multivariate analysis. Acta Pathol Microbiol Immunol Scand Suppl. 1983, 282: 1-40.PubMed
29.
Mentzel T, Calonje E, Wadden C, Camplejohn RS, Beham A, Smith MA, Fletcher CDM: Myxofibrosarcoma: clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. Am J Surg Pathol. 1996, 20 (4): 391-10.1097/00000478-199604000-00001.CrossRefPubMed
30.
Kaya M, Wada T, Nagoya S, Sasaki M, Matsumura T, Yamaguchi T, Hasegawa T, Yamashita T: MRI and histological evaluation of the infiltrative growth pattern of myxofibrosarcoma. Skeletal Radiol. 2008, 37 (12): 1085-1090. 10.1007/s00256-008-0542-4.CrossRefPubMed
31.
Ayache S, Chatelain D, Tramier B, Strunski V: Oropharyngeal and hypopharyngeal myxoma: case report and literature review. J Laryngol Otol. 2007, 121 (5): 1-4.CrossRef
Metadata
Title
Myxofibrosarcoma of the sinus piriformis: case report and literature review
Authors
Zhu Qiubei
Lin Cheng
Xu Yaping
Lin Shunzhang
Fan Jingping
Publication date
01-12-2012
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2012
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-10-245

Other articles of this Issue 1/2012

World Journal of Surgical Oncology 1/2012 Go to the issue

Case report

Primary thyroid angiosarcoma: an unusual localization

Review

En bloc resection of extra-peritoneal soft tissue neoplasms incorporating a type III internal hemipelvectomy: a novel approach

Research

Sorafenib for hepatocellular carcinoma patients beyond Milan criteria after orthotopic liver transplantation: a case control study

Case report

Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report

Research

Chromosomal structural analysis in carcinoma of the gallbladder

Research

Comprehensive geriatric assessment for older women with early breast cancer – a systematic review of literature