Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2011

Open Access 01-12-2011 | Research

Impact of osteoporosis and vertebral fractures on quality-of-life. a population-based study in Valencia, Spain (The FRAVO Study)

Authors: José Sanfélix-Genovés, Isabel Hurtado, Gabriel Sanfélix-Gimeno, Begoña Reig-Molla, Salvador Peiró

Published in: Health and Quality of Life Outcomes | Issue 1/2011

Login to get access

Abstract

Background

To describe the health related quality of life in a population sample of postmenopausal women over the age of 50 and resident in the city of Valencia (Spain), according to the presence/absence of osteoporosis and the severity of prevalent morphometric vertebral fractures.

Methods

A cross-sectional age-stratified population-based sample of 804 postmenopausal women of 50 years of age and older were assessed with the SF-12 questionnaire. Information about demographic features, lifestyle, clinical features, educational level, anti-osteoporotic and other treatments, comorbidities and risk factors for osteoporosis were collected using an interviewer-administered questionnaire and densitometric evaluation of spine and hip and spine x-rays were carried out.

Results

In the non-adjusted analysis, mild and moderate-severe vertebral fractures were associated with decreased scores in the SF-12 Physical Component Summary (PCS) but not in the Mental Component Summary (MCS), while densitometric osteoporosis with no accompanying fracture was not associated with a worse health related quality of life. In multivariate analysis worse PCS scores were associated to the age groups over 70 (-2.43 for 70-74 group and -2.97 for 75 and older), chronic conditions (-4.66, -6.79 and -11.8 according to the presence of 1, 2 or at least 3 conditions), obesity (-5.35), peripheral fracture antecedents (-3.28), hypoestrogenism antecedents (-2.61) and the presence of vertebral fracture (-2.05).

Conclusions

After adjusting for confounding factors, the physical components of health related quality of life were significantly lower in women with prevalent osteoporotic vertebral fractures than in women -osteoporotic or not- without vertebral fractures.
Appendix
Available only for authorised users
Literature
1.
Johnell O, Kanis JA: An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006,17(12):1726–33. 10.1007/s00198-006-0172-4PubMedCrossRef
2.
Majumdar SR, Kim N, Colman I, Chahal AM, Raymond G, Jen H, Siminoski KG, Hanley DA, Rowe BH: Incidental vertebral fractures discovered with chest radiography in the emergency department: prevalence, recognition, and osteoporosis management in a cohort of elderly patients. Arch Intern Med 2005,165(8):905–9. 10.1001/archinte.165.8.905PubMedCrossRef
3.
Delmas PD, van de Langerijt L, Watts NB, Eastell R, Genant H, Grauer A, Cahall DL, IMPACT Study Group: Underdiagnosis of vertebral fractures is a worldwide problem: the IMPACT study. J Bone Miner Res 2005,20(4):557–63. 10.1359/JBMR.041214PubMedCrossRef
4.
Guyatt GH, Adachi JD, Clifton J, Griffith LE, Epstein RS, Juniper EF: Quality of life issues in women with vertebral fractures due to osteoporosis. Arthritis Rheum 1993,36(6):750–6. 10.1002/art.1780360603PubMedCrossRef
5.
Lips P, van Schoor NM: Quality of life in patients with osteoporosis. Osteoporos Int 2005,16(5):447–55. 10.1007/s00198-004-1762-7PubMedCrossRef
6.
Lizán Tudela L, Badia Llach X: Quality of life evaluation for osteoporosis [In Spanish]. Aten Primaria 2003,31(2):126–33.PubMedCrossRef
7.
Peasgood T, Herrmann K, Kanis JA, Brazier JE: An updated systematic review of Health State Utility Values for osteoporosis related conditions. Osteoporos Int 2009,20(6):853–68. 10.1007/s00198-009-0844-yPubMedCrossRef
8.
Cook DJ, Guyatt GH, Adachi JD, Epstein RS, Juniper EF, Austin PA, Clifton J, Rosen CJ, Kessenich CR, Stock JL, Overdorf J, Miller PD, Erickson AL, McCLung MR, McClung BL, Griffith LE, Ioannidis G: Development and validation of the mini-osteoporosis quality of life questionnaire (OQLQ) in osteoporotic women with back pain due to vertebral fractures. Osteoporosis Quality of Life Study Group. Osteoporos Int 1999,10(3):207–13. 10.1007/s001980050217PubMedCrossRef
9.
Badia X, Díez-Pérez A, Alvarez-Sanz C, Díaz-López B, Diaz-Curiel M, Guillén F, González-Macias J, Spanish GRECO Study Group: Measuring quality of life in women with vertebral fractures due to osteoporosis: a comparison of the OQLQ and QUALEFFO. Qual Life Res 2001,10(4):307–17. 10.1023/A:1012200508847PubMedCrossRef
10.
Lips P, Cooper C, Agnusdei D, Caulin F, Egger P, Johnell O, Kanis JA, Kellingray S, Leplege A, Liberman UA, McCloskey E, Minne H, Reeve J, Reginster JY, Scholz M, Todd C, de Vernejoul MC, Wiklund I: Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis. Osteoporos Int 10(2):150–60. 10.1007/s001980050210
11.
Randell AG, Bhalerao N, Nguyen TV, Sambrook PN, Eisman JA, Silverman SL: Quality of life in osteoporosis: reliability, consistency, and validity of the Osteoporosis Assessment Questionnaire. J Rheumatol 1998,25(6):1171–9.PubMed
12.
Cantarelli FB, Szejnfeld VL, Oliveira LM, Ciconelli RM, Ferraz MB: Quality of life in patients with osteoporosis fractures: cultural adaptation, reliability and validity of the Osteoporosis Assessment Questionnaire. Clin Exp Rheumatol 1999,17(5):547–51.PubMed
13.
Lydick E, Zimmerman SI, Yawn B, Love B, Kleerekoper M, Ross P, Martin A, Holmes R: Development and validation of a discriminative quality of life questionnaire for osteoporosis (the OPTQoL). J Bone Miner Res 1997,12(3):456–63. 10.1359/jbmr.1997.12.3.456PubMedCrossRef
14.
Chandler JM, Martin AR, Girman C, Ross PD, Love-McClung B, Lydick E, Yawn BP: Reliability of an Osteoporosis-Targeted Quality of Life Survey Instrument for use in the community: OPTQoL. Osteoporos Int 1998,8(2):127–35. 10.1007/BF02672508PubMedCrossRef
15.
Badia X, Prieto L, Roset M, Díez-Pérez A: Development of the ECOS-16 clinical questionnaire for the assessment of the quality of life in patients with osteoporosis [In Spanish]. Med Clin (Barc) 2000,114(Suppl 3):68–75.
16.
Adachi JD, Adami S, Gehlbach S, Anderson FA, Boonen S, Chapurlat RD, Compston JE, Cooper C, Delmas P, Díez-Pérez A, Greenspan SL, Hooven FH, LaCroix AZ, Lindsay R, Netelenbos JC, Wu O, Pfeilschifter J, Roux C, Saag KG, Sambrook PN, Silverman S, Siris ES, Nika G, Watts NB, GLOW Investigators: Impact of Prevalent Fractures on Quality of Life: Baseline Results From the Global Longitudinal Study of Osteoporosis in Women. Mayo Clin Proc 2010,85(9):806–13. 10.4065/mcp.2010.0082PubMedCentralPubMedCrossRef
17.
van Schoor NM, Yu H, Bobula J, Lips P: Cross-geographic region differences in quality of life in women with and without vertebral fracture. Osteoporos Int 2009,20(10):1759–66. 10.1007/s00198-009-0853-xPubMedCrossRef
18.
van Schoor NM, Smit JH, Twisk JW, Lips P: Impact of vertebral deformities, osteoarthritis, and other chronic diseases on quality of life: a population-based study. Osteoporos Int 2005,16(7):749–56. 10.1007/s00198-004-1744-9PubMedCrossRef
19.
Marquis P, Cialdella P, De la Loge C: Development and validation of a specific quality of life module in post-menopausal women with osteoporosis: the QUALIOST. Qual Life Res 2001,10(6):555–66. 10.1023/A:1013041206433PubMedCrossRef
20.
de la Loge C, Sullivan K, Pinkney R, Marquis P, Roux C, Meunier PJ: Cross-cultural validation and analysis of responsiveness of the QUALIOST: QUAlity of Life questionnaire In OSTeoporosis. Health Qual Life Outcomes 2005, 3: 69. 10.1186/1477-7525-3-69PubMedCentralPubMedCrossRef
21.
Adachi JD, Ioannidis G, Pickard L, Berger C, Prior JC, Joseph L, Hanley DA, Olszynski WP, Murray TM, Anastassiades T, Hopman W, Brown JP, Kirkland S, Joyce C, Papaioannou A, Poliquin S, Tenenhouse A, Papadimitropoulos EA: The association between osteoporotic fractures and health-related quality of life as measured by the Health Utilities Index in the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int 2003,14(11):895–904. 10.1007/s00198-003-1483-3PubMedCrossRef
22.
Gold DT: The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone 1996,18(3 Suppl):185S-189S. 10.1016/8756-3282(95)00500-5PubMedCrossRef
23.
Adachi JD, Ioannidis G, Berger C, Joseph L, Papaioannou A, Pickard L, Papadimitropoulos EA, Hopman W, Poliquin S, Prior JC, Hanley DA, Olszynski WP, Anastassiades T, Brown JP, Murray T, Jackson SA, Tenenhouse A, Canadian Multicentre Osteoporosis Study (CaMos) Research Group: The influence of osteoporotic fractures on health-related quality of life in community-dwelling men and women across Canada. Osteoporos Int 2001,12(11):903–8. 10.1007/s001980170017PubMedCrossRef
24.
Tosteson AN, Gabriel SE, Grove MR, Moncur MM, Kneeland TS, Melton LJ: Impact of hip and vertebral fractures on quality-adjusted life years. Osteoporos Int 2001,12(12):1042–9. 10.1007/s001980170015PubMedCrossRef
25.
Naves Díaz M, Díaz López JB, Rodríguez Rebollar A, Gómez Alonso C, Díaz Corte C, Cannata Andía J: Effect of vertebral fracture on health related quality of life in a Spanish population older than 54 years [in Spanish]. Med Clin (Barc) 2001,116(14):533–5.CrossRef
26.
Hall SE, Criddle RA, Comito TL, Prince RL: A case-control study of quality of life and functional impairment in women with long-standing vertebral osteoporotic fracture. Osteoporos Int 1999,9(6):508–15. 10.1007/s001980050178PubMedCrossRef
27.
Cockerill W, Lunt M, Silman AJ, Cooper C, Lips P, Bhalla AK, Cannata JB, Eastell R, Felsenberg D, Gennari C, Johnell O, Kanis JA, Kiss C, Masaryk P, Naves M, Poor G, Raspe H, Reid DM, Reeve J, Stepan J, Todd C, Woolf AD, O'Neill TW: Health-related quality of life and radiographic vertebral fracture. Osteoporos Int 2004,15(2):113–9. 10.1007/s00198-003-1547-4PubMedCrossRef
28.
Hallberg I, Bachrach-Lindström M, Hammerby S, Toss G, Ek AC: Health-related quality of life after vertebral or hip fracture: a seven-year follow-up study. BMC Musculoskelet Disord 2009, 10: 135. 10.1186/1471-2474-10-135PubMedCentralPubMedCrossRef
29.
Falch JA, Bentzen H, Dahl AA: Pain, functional level and emotional problems of women with osteoporosis and vertebral fractures [in Norwegian]. Tidsskr Nor Laegeforen 2003,123(23):3355–7.PubMed
30.
Sanfélix-Genovés J, Reig-Molla B, Sanfélix-Gimeno G, Peiró S, Graells-Ferrer M, Vega-Martínez M, Giner V: The population-based prevalence of osteoporotic vertebral fracture and densitometric osteoporosis in postmenopausal women over 50 in Valencia, Spain (the FRAVO Study). Bone 2010,47(3):610–6.PubMedCrossRef
31.
Vilagut G, Valderas JM, Ferrer M, Garin O, López-García E, Alonso J: Interpretation of SF-36 and SF-12 questionnaires in Spain: physical and mental components [in Spanish]. Med Clin (Barc) 2008,130(19):726–35. 10.1157/13121076CrossRef
32.
Genant HK, Wu CY, van Kuijk C, Nevitt MC: Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 1993, 8: 1137–48. 10.1002/jbmr.5650080915PubMedCrossRef
33.
Naves M, Díaz-López JB, Gómez C, Rodríguez-Rebollar A, Rodríguez-García M, Cannata-Andía JB: The effect of vertebral fracture as a risk factor for osteoporotic fracture and mortality in a Spanish population. Osteoporos Int 2003, 14: 520–4. 10.1007/s00198-003-1405-4PubMedCrossRef
34.
Lai BM, Tsang SW, Lam CL, Kung AW: Validation of the quality of life questionnaire of the European foundation for osteoporosis (QUALEFFO-31) in Chinese. Clin Rheumatol 2010,29(9):965–72. 10.1007/s10067-010-1495-2PubMedCentralPubMedCrossRef
35.
Hopman WM, Berger C, Joseph L, Barr SI, Gao Y, Prior JC, Poliquin S, Towheed T, Anastassiades T, CaMos Research Group: The association between body mass index and health-related quality of life: data from CaMos, a stratified population study. Qual Life Res 2007,16(10):1595–603. 10.1007/s11136-007-9273-6PubMedCrossRef
Metadata
Title
Impact of osteoporosis and vertebral fractures on quality-of-life. a population-based study in Valencia, Spain (The FRAVO Study)
Authors
José Sanfélix-Genovés
Isabel Hurtado
Gabriel Sanfélix-Gimeno
Begoña Reig-Molla
Salvador Peiró
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2011
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-9-20

Other articles of this Issue 1/2011

Health and Quality of Life Outcomes 1/2011 Go to the issue

Research

Predictors of mortality and short-term physical and cognitive dependence in critically ill persons 75 years and older: a prospective cohort study

Short report

Measuring outcomes in allergic rhinitis: psychometric characteristics of a Spanish version of the congestion quantifier seven-item test (CQ7)

Research

Quality of life in Croatian Homeland war (1991-1995) veterans who suffer from post-traumatic stress disorder and chronic pain

Research

Rasch analysis of the Hospital Anxiety and Depression Scale (HADS) for use in motor neurone disease

Research

Impact of traumatic dental injuries and malocclusions on quality of life of young children

Research

The Chinese version of the Pediatric Quality of Life Inventory™ (PedsQL™) Family Impact Module: cross-cultural adaptation and psychometric evaluation