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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2013

Open Access 01-12-2013 | Research

Reliability, validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with social phobia

Authors: Michael Sonntag, Alexander Konnopka, Falk Leichsenring, Simone Salzer, Manfred E Beutel, Stephan Herpertz, Wolfgang Hiller, Jürgen Hoyer, Peter Joraschky, Björn Nolting, Karin Pöhlmann, Ulrich Stangier, Bernhard Strauss, Ulrike Willutzki, Jörg Wiltink, Eric Leibing, Hans-Helmut König

Published in: Health and Quality of Life Outcomes | Issue 1/2013

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Abstract

Objective

The aim of the study was to analyse the psychometric properties of the EQ-5D in patients with social phobia.

Methods

We used a sample of 445 patients with social phobia with five measurement points over a 30 month period. The discriminative ability of the EQ-5D was analysed by comparing the patients’ responses with the general population and between different disease severity levels. For test-retest reliability we assessed the level of agreement in patients’ responses over time, when there was no change in the Liebowitz Social Anxiety Scale (LSAS). Construct validity was analysed by identifying correlations of the EQ-5D with more specific instruments. For responsiveness we compared the means of EQ VAS/EQ-5D index anchored on improved (deteriorated) health status and computed effect sizes as well as a receiver operating characteristic (ROC) curve.

Results

Compared to the general population, patients with social phobia reported more problems in the dimensions “usual activities”, “pain/discomfort”, and “anxiety/depression” and less problems in “mobility” and “self-care”. The EQ-5D was able to distinguish between different disease severity levels. The test-retest reliability was moderate (intraclass correlation coefficient > 0.6). Correlations between the EQ-5D and other instruments were mostly small except for correlations with Beck Depression Inventory. The EQ-5D index seemed to be more responsive than the EQ VAS, but with only medium effect sizes (0.5 < effect size < 0.8) in the British EQ-5D index and only significant in patients with improved health status. The ROC analysis revealed no significant results.

Conclusions

The EQ-5D was moderately reliable and responsive in patients with improved health status. Construct validity was limited.

Trial registration

Current controlled trials ISRCTN53517394
Appendix
Available only for authorised users
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Metadata
Title
Reliability, validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with social phobia
Authors
Michael Sonntag
Alexander Konnopka
Falk Leichsenring
Simone Salzer
Manfred E Beutel
Stephan Herpertz
Wolfgang Hiller
Jürgen Hoyer
Peter Joraschky
Björn Nolting
Karin Pöhlmann
Ulrich Stangier
Bernhard Strauss
Ulrike Willutzki
Jörg Wiltink
Eric Leibing
Hans-Helmut König
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2013
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-11-215

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