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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2010

Open Access 01-12-2010 | Research

Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders

Authors: Hans-Helmut König, Anja Born, Oliver Günther, Herbert Matschinger, Sven Heinrich, Steffi G Riedel-Heller, Matthias C Angermeyer, Christiane Roick

Published in: Health and Quality of Life Outcomes | Issue 1/2010

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Abstract

Background

The EQ-5D is a generic questionnaire which generates a health profile as well as index scores for health-related quality of life that may be used in cost-utility analysis.

Aims of the study

To examine validity and responsiveness of the EQ-5D in patients with anxiety disorders.

Methods

389 patients with anxiety disorders completed the EQ-5D at baseline and 6-month follow-up. Subjective measures of quality of life (WHOQOL-BREF) and psychopathology (BAI, BDI-II, BSQ, ACQ, MI) were used for comparison. Validity was analyzed by assessing associations between EQ-5D scores and related other scores. Responsiveness was analyzed by calculating effect sizes of differences in scores between baseline and follow-up for 3 groups indicating more, constant or less anxiety. Meaningful difference scores for shifting to less or more anxiety were derived by means of regression analysis.

Results

88.4% of respondents reported problems in at least one of the EQ-5D dimension at baseline; the mean EQ VAS score was 63.8. The EQ-5D dimension most consistently associated with the measures used for comparison was 'anxiety/depression'. EQ VAS and EQ-5D index scores were highly correlated (|r|>0.5) with scores of the WHOQOL-BREF dimensions 'physical', 'mental' and 'overall' as well as BAI and BDI-II. The EQ-5D index tended to be the most responsive score. Standardized meaningful difference scores were not significantly different between EQ VAS, EQ-5D index and measures used for comparison.

Conclusions

The EQ-5D seems to be reasonably valid and moderately responsive in patients with anxiety disorders. The EQ-5D index may be suitable for calculating QALYs in economic evaluation of health care interventions for patients with anxiety disorders.

Trial registration

Current Controlled Trials ISRCTN15716049
Appendix
Available only for authorised users
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Metadata
Title
Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with anxiety disorders
Authors
Hans-Helmut König
Anja Born
Oliver Günther
Herbert Matschinger
Sven Heinrich
Steffi G Riedel-Heller
Matthias C Angermeyer
Christiane Roick
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2010
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-8-47

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