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Journal of Inflammation
Published in: Journal of Inflammation 1/2015

Open Access 01-12-2015 | Poster presentation

Characterisation of a novel vaccine delivery system for livestock

Authors: Rebecca K McLean, Ann R Wood, Jayne C Hope, Gary Entrican, David J Griffiths

Published in: Journal of Inflammation | Special Issue 1/2015

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Excerpt

Healthy animals perform better than those that are diseased; therefore there are significant benefits from preventing disease on farm by investigating new vaccine delivery systems. Recently, viral vectors have risen to prominence as candidates for generating immune responses. Of these viral candidates, lentiviruses are attractive as they have the ability to transduce non-dividing antigen presenting cells. For example, lentiviral vectors have been shown to produce an antigen-mediated immune response in mice, providing long term, sterile protection against Malaria[1]. …
Literature
1.
Coutant F, David RYS: A nonintegrative lentiviral vector-based vaccine provides long-term sterile protection against Malaria. PLoS One. 2012, 7: e48644-10.1371/journal.pone.0048644.PubMedCentralCrossRefPubMed
2.
Zufferey R, Dull T: Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J. Virol. 1998, 72: 9873-9880.PubMedCentralPubMed
3.
Gaur M, Leavitt AD: Mutations in the human immunodeficiency virus type 1 integrase D,D(35)E motif do not eliminate provirus formation. J. Virol. 1998, 72: 4678-4685.PubMedCentralPubMed
Metadata
Title
Characterisation of a novel vaccine delivery system for livestock
Authors
Rebecca K McLean
Ann R Wood
Jayne C Hope
Gary Entrican
David J Griffiths
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue Special Issue 1/2015
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/1476-9255-12-S1-P3

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