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Cardiovascular Ultrasound
Published in: Cardiovascular Ultrasound 1/2009

Open Access 01-12-2009 | Research

Head to head comparisons of two modalities of perfusion adenosine stress echocardiography with simultaneous SPECT

Authors: Petri Gudmundsson, Kambiz Shahgaldi, Reidar Winter, Magnus Dencker, Mariusz Kitlinski, Ola Thorsson, Lennart Ljunggren, Ronnie B Willenheimer

Published in: Cardiovascular Ultrasound | Issue 1/2009

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Abstract

Background

Real-time perfusion (RTP) contrast echocardiography can be used during adenosine stress echocardiography (ASE) to evaluate myocardial ischemia. We compared two different types of RTP power modulation techniques, angiomode (AM) and high-resolution grayscale (HR), with 99mTc-tetrofosmin single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia.

Methods

Patients with known or suspected coronary artery disease (CAD), admitted to SPECT, were prospectively invited to participate. Patients underwent RTP imaging (SONOS 5500) using AM and HR during Sonovue® infusion, before and throughout the adenosine stress, also used for SPECT. Analysis of myocardial perfusion and wall motion by RTP-ASE were done for AM and HR at different time points, blinded to one another and to SPECT. Each segment was attributed to one of the three main coronary vessel areas of interest.

Results

In 50 patients, 150 coronary areas were analyzed by SPECT and RTP-ASE AM and HR. SPECT showed evidence of ischemia in 13 out of 50 patients. There was no significant difference between AM and HR in detecting ischemia (p = 0.08). The agreement for AM and HR, compared to SPECT, was 93% and 96%, with Kappa values of 0.67 and 0.75, respectively (p < 0.001).

Conclusion

There was no significant difference between AM and HR in correctly detecting myocardial ischemia as judged by SPECT. This suggests that different types of RTP modalities give comparable data during RTP-ASE in patients with known or suspected CAD.
Appendix
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Metadata
Title
Head to head comparisons of two modalities of perfusion adenosine stress echocardiography with simultaneous SPECT
Authors
Petri Gudmundsson
Kambiz Shahgaldi
Reidar Winter
Magnus Dencker
Mariusz Kitlinski
Ola Thorsson
Lennart Ljunggren
Ronnie B Willenheimer
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Cardiovascular Ultrasound / Issue 1/2009
Electronic ISSN: 1476-7120
DOI
https://doi.org/10.1186/1476-7120-7-19

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